SCIENTIST 'E'
Molecular Biology


Email:  sba_bio@ninindia.org

Email:  sba_bioc@yahoo.com

Brief Profile

Dr. Sanjay Basak completed his doctor of philosophy (Ph.D.) in Biochemistry. He joined the ICMR-National Institute of Nutrition (NIN), India on August, 2004. He is a skilled and independent researcher with more than thirteen years of experience in the area of molecular nutrition, metabolism and reproductive physiology. At present, he is working as Faculty Scientist affiliated as Assistant Director at NIN. His present research investigates the roles of nutritional and environmental factors on early placental & fetal development and its potential contribution to the development of adult chronic diseases.  His research aims to investigate how nutrition modulates the placentation by using human cells, models (rat and mice), clinical cases and molecular diagnostic methods.

Dr. Basak did his postdoctoral research work (2010-11 & 2016-17) at Institute of Basic Medical Sciences, University of Oslo (UiO), Norway. He is a recipient of HRD (Human Resource Development) fellowship grant and award by Department of Health Research, Govt. of India in 2016. Dr. Basak is a recipient of BOYSCAST (Better Opportunities for Young Scientists in Chosen Areas of Science & Technology) fellowship grant and award by Dept. of Science & Technology, Govt. of India in 2010. He received Henrik Homans Memorial Scholarship awarded by UiO, Norway. He is a Life Member of Nutrition Society of India, Indian Society for the Study of Reproduction & Fertility, Indian Society of Cell Biology. Dr. Basak is currently working as one of the editorial board members for the International journal “Food & Nutrition Research”, Swedish Nutrition Foundation. Dr. Basak authored more than thirty-five articles that included original research, review papers, book chapters, edited book and monograph.

Total publications in Peer reviewed Journal : 16; List of Publications in last 10 years
1. Basak S, Vilasagarm S, Duttaroy,A.K Bisphenol-A impairs cellular function and alters DNA methylation of stress pathway genes in first trimester trophoblast cells, Reproductive Toxicology, 82 (2018) 72-79. PMID: 30352284

2. Basak S, Vilasagaram S, Naidu K, Duttaroy AK. Insulin-dependent, glucose transporter 1 mediated glucose uptake and tube formation in the human placental first trimester trophoblast cells. Mol Cell Biochem. 2018;Accepted 26 June 2018. PMID: 30003444.

3. Basak S, Sarkar A, Mathapati S, Duttaroy AK. Cellular growth and tube formation of HTR8/SVneo trophoblast: effects of exogenously added fatty acid-binding protein-4 and its inhibitor. Mol Cell Biochem. 2018;437(1-2):55-64. PMID: 28620819

4. Leroy C, Tobin KAR, Basak S, Cathrine Staff A, Duttaroy AK. Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2017;120:1-7. PMID: 28515017

5. Basak S, Duttaroy A. Cellular effects of the endocrine disrupters (Bisphenol-S & A): impact on the growth and development of the first trimester trophoblast cells. Placenta. 2017;57:253. DOI: https://doi.org/10.1016/j.placenta.2017.07.104

6. Pandya AD, Das MK, Sarkar A, Vilasagaram S, Basak S, Duttaroy AK. Tube formation in the first trimester placental trophoblast cells: Differential effects of angiogenic growth factors and fatty acids. Cell biology international. 2016;40(6):652-61. PMID: 26992362

7. Patwardhan S, Dasari S, Bhagavatula K, Deepak SA, Ghosh S, Basak S. Simultaneous Detection of Genetically Modified Organisms in a Mixture by Multiplex PCR-Chip Capillary Electrophoresis. Journal of AOAC International. 2015;98(5):1366-74. PMID: 26525256

8. Basak S, Das MK, Srinivas V, Duttaroy AK. The interplay between glucose and fatty acids on tube formation and fatty acid uptake in the first trimester trophoblast cells, HTR8/SVneo. Mol Cell Biochem. 2015;401(1-2):11-9. PMID: 25413343

9. Das MK, Basak S, Ahmed MS, Attramadal H, Duttaroy AK. Connective tissue growth factor induces tube formation and IL-8 production in first trimester human placental trophoblast cells. Eur J ObstetGynecolReprod Biol. 2014;181C:183-8. PMID: 25150958.

10. Basak S, Ehtesham NZ, Sesikeran B, Ghosh S. Detection and identification of transgenic elements by fluorescent-PCR-based capillary gel electrophoresis in genetically modified cotton and soybean. J AOAC Int. 2014;97(1):159-65. PMID: 24672872

11. Basak S, Duttaroy AK. cis-9,trans-11 conjugated linoleic acid stimulates expression of angiopoietin like-4 in the placental extravillous trophoblast cells. BiochimBiophysActa. 2013;1831(4):834-43. PMID: 23354176

12. Basak S, Duttaroy AK. Effects of fatty acids on angiogenic activity in the placental extravillious trophoblast cells. Prostaglandins LeukotEssent Fatty Acids. 2013;88(2):155-62. PMID: 23153451

13. Basak S, Das MK, Duttaroy AK. Fatty acid-induced angiogenesis in first trimester placental trophoblast cells: possible roles of cellular fatty acid-binding proteins. Life sciences. 2013;93(21):755-62. PMID: 24095946

14. Duttaroy A, Basak S. Docosahexaenoic acid and angiogenesis: a role in early placentation. ClinLipidol. 2012;7(3):303-12. https://doi.org/10.2217/clp.12.19

15. Basak S, Duttaroy AK. Leptin induces tube formation in first-trimester extravillous trophoblast cells. Eur J ObstetGynecolReprod Biol. 2012;164(1):24-9.

16. Johnsen GM, Basak S, Weedon-Fekjaer MS, Staff AC, Duttaroy AK. Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. Placenta. 2011;32:626-32. PMID: 21741084

17. Ibrahim A, Ghafoorunissa, Basak S, Ehtesham NZ. Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. Br J Nutr. 2009;102(2):233-41. PMID: 19166630

Total number of books = 2; Book chapters =15

Books

  1. Asim K Duttaroy, Sanjay Basak (2016) Early Nutrition and Lifestyle Factors: Effects on First Trimester Placenta. Springer International Publishing, Switzerland. http://www.springer.com/us/book/9783319388021
  2. Asim K Duttaroy, Sanjay Basak (2015) eds. Human Placental Trophoblast: Impacts on Maternal Nutrition. CRC press, Taylor & Francis Group, USA. http://www.crcpress.com/product/isbn/9781482254280

Book chapters

  1. Early Placentation Processes: DOI: 10.1007/978-3-319-38804-5_2 In book: Early Nutrition and Lifestyle Factors, 2016 pp.13-21
  2. Glucose and Amino Acid and Their Roles in Placentation: DOI: 10.1007/978-3-319-38804-5_3 In book: Early Nutrition and Lifestyle Factors, 2016 pp.23-38
  3. B Vitamins and Their Role on Trophoblast Growth and Development: DOI: 10.1007/978-3-319-38804-5_5 In book: Early Nutrition and Lifestyle Factors, 2016 pp.51-68.  
  4. Endocrine Factors and Their Effects on Placentation: DOI: 10.1007/978-3-319-38804-5_7 In book: Early Nutrition and Lifestyle Factors, 2016 pp.91-100
  5. Sources of Key Nutrients for Successful Placentation: DOI: 10.1007/978-3-319-38804-5_12 In book: Early Nutrition and Lifestyle Factors, 2016 pp.151-159
  6. Placentation as a Predictor of Feto-Placental Outcome: Effects of Early Nutrition: DOI: 10.1007/978-3-319-38804-5_1 In book: Early Nutrition and Lifestyle Factors, 2016 pp.1-12
  7. Dietary Fatty Acids and Placentation: DOI: 10.1007/978-3-319-38804-5_4 In book: Early Nutrition and Lifestyle Factors, 2016 pp.39-50
  8. Maternal Lifestyle Factors and Placentation: DOI: 10.1007/978-3-319-38804-5_8 In book: Early Nutrition and Lifestyle Factors, 2016 pp.101-118
  9. Placental Epigenetics and Its Importance in Placental Development: DOI: 10.1007/978-3-319-38804-5_10  In book: Early Nutrition and Lifestyle Factors, 2016, pp.129-137
  10. 10.Fat-Soluble and Antioxidant Vitamins and Minerals: Their Roles in Placentation: DOI: 10.1007/978-3-319-38804-5_6  In book: Early Nutrition and Lifestyle Factors, 2016 pp.69-89
  11. Regulation of Placentation by Environmental Factors: DOI: 10.1007/978-3-319-38804-5_9 In book: Early Nutrition and Lifestyle Factors, 2016, pp.119-128
  12. Gene Regulation, microRNA, and Placentation; DOI: 10.1007/978-3-319-38804-5_11 · In book: Early Nutrition and Lifestyle Factors, 2016, pp.139-149
  13. Basak S and Duttaroy AK (2015) Hyperglycemia on trophoblast invasion and angiogenesis, Chapter 20 ; Edited by Asim K Duttaroy, Sanjay Basak, Human Placental Trophoblasts: Impacts on Maternal Nutrition. CRC press, Taylor & Francis Group, USA
  14. Basak S and Duttaroy AK (2015) Fatty acid and placentation, Chapter 11 ; Edited by Asim K Duttaroy, Sanjay Basak, Human Placental Trophoblasts: Impacts on Maternal Nutrition. CRC press, Taylor & Francis Group, USA
  15. Duttaroy AK and Basak S (2013) Docosahexaenoic Acid and Angiogenesis: A Review Nutrition and Health: Omega-6/3 Fatty Acids, Edited by: F. De Meester et al., Chapter 11, Page193,©Humana Press (Springer Science) Business Media New York
Awards and Honours
  1. 2018 : Smt.Swaran Kanta Dingley Oration award by Indian Council of Medical Research (ICMR), Govt. of India for the outstanding research contribution in Reproductive Biology
  2. 2016-17: Human Resource Development Fellowship and Award by Dept. of Health Research, Govt of India.
  3. 2015-till date:    Editorial board member of the International Journal “Food & Nutrition Research”, Published by Swedish Nutrition Foundation.
  4. 2011: Henrik Homans Memorial Scholarship, UNIFOR, University of Oslo, Norway.
  5. 2010-11: BOYSCAST (Better Opportunity for Young Scientist in the Chosen Area of Science & Technology) fellow , Dept. of Science & Technology, Govt. of India.