CELL & MOLECULAR BIOLOGY


The Molecular Biology Division is involved in understanding the molecular mechanisms of development of nutritional disorders like obesity and diabetes, zinc deficiency, nutrient transport through placenta. Using a diet-induced obesity model, they have shown infiltration and cross-talk of T cells with adipose tissue. Using cutting edge technologies like NGS and realtime PCR, they are trying to understand gene-nutrient and gene-gene interaction during development of these nutritional disorders. They are also studying how the metabolic stress is translated into inflammation at the endoplasmic reticulum into ER stress. They are also working towards development of early molecular biomarkers for diabetes, zinc deficiency by studying the circulating miRNA profiles in different cohorts using NGS. They are also studying the impact of glucose and fatty acids for placental development during gestation. They demonstrated that DHA (docosahexaenoic acid) stimulates the synthesis of angiogenic factor VEGF with concomitant increase in angiogenesis of the placental cells. Since, glucose acts as an energy substrate for developing a fetus, optimal glucose transporter-1 activity is required for the growth and development of the placenta which reduces IUGR. In addition, they are also studying host-pathogen interaction and role of gene-nutrient interactions in defining the outcome of an infection.


STAFF

  1. Dr. Sudip Ghosh, Scientist ā€˜Fā€™
  2. Dr. Sanjay Basak, Scientist ā€˜Eā€™
  3. Virendra Panpatil, Senior Technical Officer-2
  4. S. Laxman, Technical Officer