Scientist ‘D’ 

Contact:  +91-40-27197472

Brief Profile

After receiving her Ph.D. in the area of Molecular & Cellular Biology from University of Hyderabad in 2006, she pursued postdoctoral research work at the Department of Pharmacology, University of Cambridge, UK till 2008 in the area of calcium imaging and ion channels, followed by further research at the Division of Diabetes, Endocrinology and Metabolism, Imperial College London, UK where she carried out a wide range of research activities starting from MODY (maturity onset diabetes of the young) clinical presentations, gene mutations and cellular signalling, pancreatic alpha and beta cell signaling in insulin secretion and glucose homeostasis, Ca2+, Zn2+ and small molecule live-imaging in beta cells, functional genomics of mutations associated with type 2 diabetes in the post genome-wide association studies (GWAS) phase. In 2016, Dr. Gargi joined as Assistant Editor (Scientist ‘D’) of Indian Journal of Medical Research (IJMR), which is a peer-reviewed, international monthly journal published by ICMR-Wolters Kluwer Medknow, and is based in ICMR Head Qtrs. IJMR team brought out three Special issues and five Supplements in past 3 years, in addition to the regular monthly issues of IJMR. Special Issues: Challenges in Control of Smokeless Tobacco (July, 2018); Nutrition Research (Nov, 2018); Antimicrobial Resistance Surveillance System (Feb, 2019). Supplements: Biomedical Research: Oncology (May, 2016); Microbes & Health (July, 2017); Research in Non-Communicable Diseases (Nov, 2017); Reproductive Health with Emphasis On Strategy For Infertility (Dec, 2018); and Gandhi and Health @150 (Jan, 2019). In May 2016, she has moved to ICMR-NIN and joined as Scientist D at the Division of Clinical Epidemiology and initiated community-based research activities. Her research interests include Ca2+, Zn2+ and small molecule imaging in excitatory cells, glucose metabolism and diabetes, gut microbiota in regulating metabolic homeostasis, antimicrobial resistance transmission.

Publications (Total 23; Total citation 553; h-index 15 (Scopus) & 17 (Google scholar)
  1. Meur G, et al. Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention. Diabetes 2010; 59 (3):653-61.
  2. Noordeen NA, Meur G, et al. Glucose-induced nuclear shuttling of ChREBP is mediated by Sorcin and Ca2+ ions in pancreatic β-cells. Diabetes 2012; 61 (3):574-85.
  3. Meur G, et al. Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6). J Biol Chem 2011; 286 (15):3647-56.
  4. Meur G, et al. Targeting and retention of type 1 ryanodine receptors to the endoplasmic reticulum. J Biol Chem 2007; 282(32):23096-103.
  5. Solomou A, Meur G, et al. The Zinc Transporter Slc30a8/ZnT8 Is Required in aSubpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion. J Biol Chem 2015; 290(35):21432-42.
  6. Bellomo EA, Meur G, Rutter GA. Glucose regulates free cytosolic Zn2+ concentration, Slc39 (ZiP) and metallothionein gene expression in primary pancreatic islet beta-cells. J Biol Chem 2011; 286(29):25778-89.
  7. Rosker C, Meur G, et al. Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells. J Biol Chem 2009; 284(8):5186-94. (Commentary in Islets, 1, 82-84).
  8. Mitchell RK, Hu M, Chabosseau PL, Cane MC, Meur G, et al. Molecular Genetic Regulation ofSlc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance. Mol Endocrinol 2016; 30 (1):77-91.
  9. Seillier M, Pouyet L, N’guessan P, Nollet M, Capo F, Peyta L, Varrault A, Bertrand, G Guillaumond F, Meur G, et al. Tumor Protein 53-Induced Nuclear Protein 1 prevents metabolic syndrome by regulating mitochondrial-elicited oxidative stress and lipid metabolism. EMBO Mol Med 2015; pii: e201404318.
  10. Chabosseau P, Tuncay E, Meur G, et al. Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+. ACS Chem Biol 2014; 9 (9):2111-20.
  11. Gerber PA, BellomoEA, Hodson DJ, Meur G, et al. Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+in pancreatic beta cells. Diabetologia 2014; 57 (8):1635-44.


Awards and Honors

EASD Travel grant to attend 47th EASD Annual Meeting at Stockholm; Twice qualified CSIR-UGC-NET-JRF for PhD (2000, 2002), ICAR-JRF for MSc (1998-2000).