M.Sc., Ph.D. (Biochemistry), Scientist-C
Biochemistry Division

Email:  sreenivasareddys@gmail.com
Contact:  +91-40-27197372

Brief Profile

I received Ph.D (2009) in Biochemistry, and the research work was on identifying therapeutics from natural sources for insulin resistance employing animal model. My current research area is Nutrition and dietary based interventional studies in preventing/treating age-related and lifestyle diseases with special emphasis on diabetic complications. We revealed the effect of obesity on the brain Ubiquitin-Proteasome System and its possible underlying mechanisms in neurodegeneration including modulation of Endoplasmic Reticulum (ER) Stress. Added, we demonstrated the beneficiary outcome of dietary restriction in obesity on neurodegeneration. We performed exploratory studies on the role of Ubiquitin-Proteasome System and ER Stress in the development of diabetic complications like retinopathy and myopathy. The pathological role of ER stress in diabetic myopathy was studied in type-I diabetes. Further 4-PBA, a well-known ER stress inhibitor was proved to avert diabetic muscle wasting in streptozotocin-induced diabetic rat. Currently, work is in progress to decipher the potential role of few nutrients and dietary ingredients in preventing diabetic complications using in vitro and in vivo models.

Publications | Total Publications: 27

List of publications in last 10 years

  1. Reddy SS, Prabhakar YK, Kumar CU, Reddy PY, Reddy GB. Effect of vitamin B12 supplementation on retinal lesions in diabetic rats. Mol Vis. 2020 Apr 24;26:311-325. PMID: 32355441
  2. Godisela KK, Reddy SS, Reddy PY, Kumar CU, Reddy VS, Ayyagari R, Reddy GB. Role of sorbitol-mediated cellular stress response in obesity-associated retinal degeneration. Arch Biochem Biophys. 2020 Jan 15;679:108207. PMID: 31760123
  3. Srinivasarao DA, Reddy SS, Reddy GB, Katti DS. Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract. Int J Pharm. 2019 Sep 10;568:118474. PMID: 31279055
  4. Reddy SS, Shruthi K, Joy D, Reddy GB. 4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system. Chem Biol Interact. 2019 Jun 1;306:70-77. PMID: 30980806
  5. Shruthi K, Reddy SS, Chitra PS, Reddy GB. Ubiquitin-proteasome system and ER stress in the brain of diabetic rats. J Cell Biochem. 2019 Apr;120(4):5962-5973. PMID: 30317658
  6. Gopalakrishnan S, Ediga HH, Reddy SS, Reddy GB, Ismail A. Procyanidin-B2 enriched fraction of cinnamon acts as a proteasome inhibitor and anti-proliferative agent in human prostate cancer cells. IUBMB Life. 2018 May;70(5):445-457. PMID: 29537730
  7. Reddy SS, Shruthi K, Prabhakar YK, Sailaja G, Reddy GB. Implication of altered ubiquitin-proteasome system and ER stress in the muscle atrophy of diabetic rats. Arch Biochem Biophys. 2018 Feb 1;639:16-25. PMID: 29277369
  8. Shruthi K, Reddy SS, Reddy GB. Ubiquitin-proteasome system and ER stress in the retina of diabetic rats. Arch Biochem Biophys. 2017 Aug 1;627:10-20. PMID: 28606465
  9. Godisela KK, Reddy SS, Kumar CU, Saravanan N, Reddy PY, Jablonski MM, Ayyagari R, Reddy GB. Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome. Mol Vis. 2017 Apr 14;23:263-274. PMID: 28465658
  10. Shruthi K, Reddy SS, Reddy PY, Shivalingam P, Harishankar N, Reddy GB. Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. J Nutr Biochem. 2016 Jul;33:73-81. PMID: 27260470
  11. Reddy SS, Shruthi K, Reddy VS, Raghu G, Suryanarayana P, Giridharan NV, Reddy GB. Altered ubiquitin-proteasome system leads to neuronal cell death in a spontaneous obese rat model. Biochim Biophys Acta. 2014 Sep;1840(9):2924-34. PMID: 24949983
  12. Reddy VS, Raghu G, Reddy SS, Pasupulati AK, Suryanarayana P, Reddy GB. Response of small heat shock proteins in diabetic rat retina. Invest Ophthalmol Vis Sci. 2013 Nov 19;54(12):7674-82. PMID: 24159092
  13. Ramesh B, Karuna R, Reddy SS, Sudhakara G, Saralakumari D. Ethanolic Extract of Commiphora Mukul Gum Resin Attenuates Streptozotocin-Induced Alterations in Carbohydrate and Lipid Metabolism in Rats. EXCLI J . 2013 Jun 19;12:556-68. PMID: 27004047
  14. Karuna R, Ramesh B , Reddy SS, Saralakumari D. Abnormalities in carbohydrate and lipid metabolisms in high-fructose dietfed insulin-resistant rats: amelioration by Catharanthus roseus treatments. J Physiol Biochem . 2013 Sep;69(3):459-66. PMID: 23334857
  15. Ramesh B, Karuna R, Sreenivasa RS, Haritha K, Sai MD, Sasi BR, Saralakumari D. Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats. Asian Pac J Trop Biomed. 2012 Nov;2(11):895-900. PMID: 23569867
  16. Bellamkonda R, Rasineni K, Singareddy SR, Kasetti RB, Pasurla R, Chippada AR, Desireddy S. Antihyperglycemic and antioxidant activities of alcoholic extract of Commiphora mukul gum resin in streptozotocin induced diabetic rats. Pathophysiology. 2011 Sep;18(4):255-61. PMID: 21767936
  17. Karuna R, Bharathi VG, Reddy SS, Ramesh B, Saralakumari D. Protective effects of Phyllanthus amarus aqueous extract against renal oxidative stress in Streptozotocin -induced diabetic rats. Indian J Pharmacol. 2011 Jul;43(4):414-8. PMID: 21844996
  18. Reddy SS, Ramatholisamma P, Karuna R, Saralakumari D. Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. Food Chem Toxicol. 2009 Sep;47(9):2224-9. PMID: 19520137
  19. Karuna R, Reddy SS, Baskar R, Saralakumari D. Antioxidant potential of aqueous extract of Phyllanthus amarus in rats. Indian J Pharmacol. 2009 Apr;41(2):64-7. PMID: 20336219
  20. Reddy SS, Ramatholisamma P, Ramesh B, Baskar R, Saralakumari D. Beneficiary effect of Tinospora cordifolia against high-fructose diet induced abnormalities in carbohydrate and lipid metabolism in Wistar rats. Horm Metab Res. 2009 Oct;41(10):741-6. PMID: 19764107
  21. Reddy SS, Karuna R, Baskar R, Saralakumari D. Prevention of insulin resistance by ingesting aqueous extract of Ocimum sanctum to fructose-fed rats. Horm Metab Res. 2008 Jan;40(1):44-9. PMID: 18085503

Book Chapters:

1. Reddy SS, Reddy GB and Krishnaswamy K. Case studies on functional foods-Health benefits of turmeric (Curcumin longa Linn). In: Functional Foods Monographs 2017. Publisher: International Life Sciences Institute, Washington DC, USA.

Awards and Honors
  1. CSIR- Senior Research Associateship: 2018
  2. SERB- Young Investigator: 2013
  3. ICMR- Centenary Post-Doctoral Research Fellow: 2010