Received Ph. D (2009) in Biochemistry, and the research work was on identifying therapeutics from natural sources for insulin resistance by employing animal models. The current research area is Nutrition and dietary-based interventional studies in preventing/treating age-related/ lifestyle - diseases with special emphasis on diabetes and obesity complications. We revealed the effect of obesity on the brain Ubiquitin-Proteasome System and its possible underlying mechanisms in neurodegeneration including modulation of Endoplasmic Reticulum Stress. We demonstrated the beneficiary outcome of dietary restriction in obesity-induced neurodegeneration. Our studies revealed a role for micronutrients in combating diabetic complications and the molecular mechanisms involved. We also explore the effect of micronutrient deficiencies on certain cell signaling pathways. Currently, work is in progress to elucidate the potential role of vitamins in the development and functioning of the brain and retina.

List of publications in last 10 years

1. Nagaraju M, Kalahasti KK, Reddy KP, Addi UR, Satyavani M, Reddy GB, Reddy SS. Anti-inflammatory potential of turmeric, amla, and black pepper mixture against sepsis-induced acute lung injury in rats. J Food Sci Technol. 2023 Jan;60(1):252-261. PMID: 36349282.
2. Kumar CU, Reddy SS, Suryanarayana P, Patil MA, Chary PM, Kumar PU, Reddy GB. Protective effect of cinnamon on diabetic cardiomyopathy in nicotinamide-streptozotocin induced diabetic rat model. J Diabetes Metab Disord. 2022 Jan 21;21(1):141-150. PMID: 35673461.
3. Reddy SS, Addi UR, Pullakhandam R, Reddy GB. Dietary zinc deficiency disrupts skeletal muscle proteostasis and mitochondrial biology in rats. Nutrition. 2022 Jun;98:111625. PMID: 35439650.
4. Padakandla SR, Das T, Sai Prashanthi G, Angadi KK, Reddy SS, Reddy GB, Shivaji S. Gut mycobiome dysbiosis in rats showing retinal changes indicative of diabetic retinopathy. PLoS One. 2022 Apr 19;17(4):e0267080. PMID: 35439275.
5. Reddy Addi U, Jakhotia S, Reddy SS, Reddy GB. Age-related neuronal damage by advanced glycation end products through altered proteostasis. Chem Biol Interact. 2022 Mar 1;355:109840. PMID: 35104490.
6. Srinivasarao DA, Reddy SS, Reddy GB, Katti DS. Simultaneous amelioration of diabetic ocular complications in lens and retinal tissues using a non-invasive drug delivery system. Int J Pharm. 2021 Oct 25;608:121045. PMID: 34481006.
7. Padakandla SR, Das T, Sai Prashanthi G, Angadi KK, Reddy SS, Reddy GB, Shivaji S. Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes. Invest Ophthalmol Vis Sci. 2021 Aug 2;62(10):31. PMID: 34431974.
8. Reddy SS, Prabhakar YK, Kumar CU, Reddy PY, Reddy GB. Effect of vitamin B12 supplementation on retinal lesions in diabetic rats. Mol Vis. 2020 Apr 24;26:311-325. PMID: 32355441
9. Godisela KK, Reddy SS, Reddy PY, Kumar CU, Reddy VS, Ayyagari R, Reddy GB. Role of sorbitol-mediated cellular stress response in obesity-associated retinal degeneration. Arch Biochem Biophys. 2020 Jan 15;679:108207. PMID: 31760123
10. Srinivasarao DA, Reddy SS, Reddy GB, Katti DS. Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract. Int J Pharm. 2019 Sep 10;568:118474. PMID: 31279055
11. Reddy SS, Shruthi K, Joy D, Reddy GB. 4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system. Chem Biol Interact. 2019 Jun 1;306:70-77. PMID: 30980806
12. Shruthi K, Reddy SS, Chitra PS, Reddy GB. Ubiquitin-proteasome system and ER stress in the brain of diabetic rats. J Cell Biochem. 2019 Apr;120(4):5962-5973. PMID: 30317658
13. Gopalakrishnan S, Ediga HH, Reddy SS, Reddy GB, Ismail A. Procyanidin-B2 enriched fraction of cinnamon acts as a proteasome inhibitor and anti-proliferative agent in human prostate cancer cells. IUBMB Life. 2018 May;70(5):445-457. PMID: 29537730
14. Reddy SS, Shruthi K, Prabhakar YK, Sailaja G, Reddy GB. Implication of altered ubiquitin-proteasome system and ER stress in the muscle atrophy of diabetic rats. Arch Biochem Biophys. 2018 Feb 1;639:16-25. PMID: 29277369
15. Shruthi K, Reddy SS, Reddy GB. Ubiquitin-proteasome system and ER stress in the retina of diabetic rats. Arch Biochem Biophys. 2017 Aug 1;627:10-20. PMID: 28606465
16. Godisela KK, Reddy SS, Kumar CU, Saravanan N, Reddy PY, Jablonski MM, Ayyagari R, Reddy GB. Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome. Mol Vis. 2017 Apr 14;23:263-274. PMID: 28465658
17. Shruthi K, Reddy SS, Reddy PY, Shivalingam P, Harishankar N, Reddy GB. Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. J Nutr Biochem. 2016 Jul;33:73-81. PMID: 27260470
18. Reddy SS, Shruthi K, Reddy VS, Raghu G, Suryanarayana P, Giridharan NV, Reddy GB. Altered ubiquitin-proteasome system leads to neuronal cell death in a spontaneous obese rat model. Biochim Biophys Acta. 2014 Sep;1840(9):2924-34. PMID: 24949983
19. Reddy VS, Raghu G, Reddy SS, Pasupulati AK, Suryanarayana P, Reddy GB. Response of small heat shock proteins in diabetic rat retina. Invest Ophthalmol Vis Sci. 2013 Nov 19;54(12):7674-82. PMID: 24159092
20. Ramesh B, Karuna R, Reddy SS, Sudhakara G, Saralakumari D. Ethanolic Extract of Commiphora Mukul Gum Resin Attenuates Streptozotocin-Induced Alterations in Carbohydrate and Lipid Metabolism in Rats. EXCLI J. 2013 Jun 19;12:556-68. PMID: 27004047
21. Karuna R, Ramesh B, Reddy SS, Saralakumari D. Abnormalities in carbohydrate and lipid metabolisms in high-fructose diet-fed insulin-resistant rats: amelioration by Catharanthus roseus treatments. J Physiol Biochem. 2013 Sep;69(3):459-66. PMID: 23334857