Scientist 'D',
CELL BIOLOGY



Email:  arajanna@gmail.com
Contact:  +91-40-27197245

Brief Profile

Dr. A. Rajanna has obtained his Master’s degree in Pharmaceutical Sciences from Kakatiya University, Warangal, Telangana State in the year 2002 with GATE fellowship. He has obtained his Ph.D. in Biochemistry from Osmania University. His research interests include Biochemistry, Cell Biology, Cancer Biology, Nutritional Biochemistry and Pharmacy. His present research is focused on exploration of micronutrients as anti-cancer agents with special emphasis to target cancer stem cells along with cancer cells. From last couple of years working on role of micronutrients on cancer stem cells metabolism and therapy in normal and drug resistant breast cancer cells. Also interested in studying of differentiation pattern of cancer stem cells to cancer cells in presence of micronutrients and drugs. The techniques like gene expression studies, cell cycle regulation pattern, apoptosis, RT-PCR, Immunohistochemistry have been used to understand the potency of micronutrients along with standard drugs for combination therapy in cancer disease. He has experience in working with different in vitro cell culture facility to understand the micronutrients and drugs metabolism. He is a recipient of DBT Young Investigator Award with Project Grant. He serves as a faculty for different courses taught at NIN. .

Total publications : 18
  1. Rishika J, Naresh V, Rajanna A and Suresh C, Isoflavones rich cowpea and vitamin D induces the proliferation and differentiation of human osteoblasts via BMP2/Smad pathway activation: Mechanistic approach; IUBMB Life 2019; 1-12, DOI: 10.1002/iub.2127. (I.F: 3.24).
  2. Rajanna A, Ganapathi T and Vijayalakshmi V, Synthesis and Evaluation of Triazolyl Dihydropyrimidines as Potential Anticancer Agents, International Journal of Chemistry; 2018, 10 (4), 18-27.
  3. Ganapathi T, Rajanna A, Vijayalakshmi V, Novel dihydropyrimidine derivatives as potential HDAC inhibitors: in silico study. Insilico pharmacol. 2017, vol.5 :10 DOI 10.1007/s40203-017-0030-4
  4. Neelima A, Rajanna A , Reddy GB, Chetty CS , Suresh C;  Deleterious effects of combination of lead and β-amyloid peptides in inducing apoptosis and altering cell cycle in human neuroblastoma cells. Interdiscip Toxicol. 2017; Vol. 10(3): 101–106.  doi: 10.1515/intox-2017-0015 (I.F: 1.24)
  5. Ganapathi T and Rajanna A, Vijayalakshmi V, Novel dihydropyrimidine derivatives as potential HDAC inhibitors: In silico study,  In Silico Pharmacology, 2017, 5:10, https://doi.org/10.1007/s40203-017-0030-4
  6. Himadri Singh, Rajanna Ajumeera, Venkata Malakapalli, Maniprabha Chalasani, Suresh Pothani, Vijayalakshmi Venkatesan,  WNIN Mutant Obese Rats Develop Acute pancreatitis With the Enhanced Inflammatory Milieu, Cell Mol Med Res. 2017;1(1):20-31.
  7. Rishika J, Vijayalakshmi V, Rajanna A and Suresh C, Possible synergetic role of cowpea isoflavones and vitamin D combo in the bone formation of MG-63 osteoblasts, Vitamins&Minarals, 2016; 5: 3(IF: 1.5)
  8. Ayesha I, Bindu N, Ramesh G, Shyam P, Rajanna A, Suresh B, Molecular docking of murraya koenigii leaf alkaloids with 20S proteosome inhibitory activity of total alakalois extract and mahanine in breast cancer cells, Journal of Medicinal Plants 2016; 19 (12): 1155-1165 (IF:1.8)
  9. Rajanna A, Novel approach to target cancer stem cells for therapy, Medical Hypotheses, 2016; 88: 83-85. Doi: 10.1016/j.mehy.2015.11.009 (IF:1.5)
  10. Ravi M, Chennam KP, Ushaiah B, Eslavath RK, Perugu S, Rajanna A, Devi CS, A Study on Spectro-Analytical Aspects, DNA - Interaction, Photo-Cleavage, Radical Scavenging, Cytotoxic Activities, Antibacterial and Docking Properties of 3 - (1 - (6 - methoxybenzo [d] thiazol - 2 - ylimino) ethyl) - 6 - methyl - 3H - pyran - 2, 4 - dione and its Metal Complexes, Journal of  Fluorescence. 2015, PMID: 26315729(I.F:2.6)
  11. Rajesh M, Rajanna A, Vijayalakshmi V, Balakrishna MP. Proliferation and TH1/TH2 cytokine production in human peripheral blood mononuclear cells after treatment with cypermethrin and mancozeb in vitro. Journal of Toxicology 2014; doi.org/10.1155/2014/308286 (I.F:0.8)
  12. Vijayalakshmi V, Soundarya M,Sowmya K, Sireesha G, Rajanna A, Venkata M, Raghunath M, Modelling developmental origins of adult based diseases (obesity) using mesenchymal stem – cellular, molecular and functional approaches, Journal of Developmental Origins of Health and Disease 2013, 4, (2): S51–S339
  13. Noolu B, Rajanna A, Chauhan A, Nagalla B, Manchala R, Ismail A, Murraya koenigii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells, BMC Complement Altern Med, 2013; 9(13):7, doi: 10.1186/1472-6882-13-7. I.F: 2.7)
  14. Soundarya L, Satya SC, Maniprabha C, Giridharan N, Ramesh RB, Rajanna A, Vijayalakshmi V, Promise(s) of Mesenchymal Stem Cells as an In Vitro Model System to Depict Pre-Diabetic/Diabetic Milieu in WNIN/GR-Ob Mutant Rats, PLOS ONE,  2012; 7 (10e48061). (I.F: 3.4)
  15. Prabhakar K, Afzal SM, Kumar PU, Rajanna A, Kishan V, Brain delivery of tranferrin coupled indinavir submicron lipid emulsion- pharmacokinetics and tissue distribution, Colloids Surf B Bio interfaces, 2011; 1;86(2):305-13. doi: 10.1016. (I.F: 3.5)
  16. Radha V, Rajanna A, Gupta RK, Dayma K, Raman T; The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells. Journal of Neurochemistry, 2008; 107(5): 1424-35. (I.F; 4.0)
  17. Asmita G, Rajanna A, Shailendra P, Achaiah G, Synthesis and pharmacological evaluation of 1-(4-chlorobenzyl)-6-substituted 4-oxo-quinolin-3-(N-substituted/N, N-disubstituted) carboxamides, Oriental Journal of Chemistry, 2007 Vol. 23(3) :835-842.
  18. Radha V, Rajanna A, Mitra A, Rangaraj N, Swarup G; C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation, Exp Cell Res, 2007 Jul 1;313(11):2476-92. Epub 2007 Mar 30. Erratum in: Exp Cell Res, 2007,10; 313(15): 3376. (I.F: 3.7).
  19. Radha V, Rajanna A, Swarup G, Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton. BMC Cell Biol, 2004; 20, 5(1): 31. (I.F:3.4)
List of Books : 01

1. Recent advances and Challenges in Reproductive Health Research; Editors: R. S. Sharma, A.Rajanna, M. Rajalakshmi, Proceeding of the conference held on 19th-21st February, 2007, New Delhi. Division of Reproductive Health and Nutrition, Indian Council of Medical Research and Nutrition.

List of Book chapters : 05
  1. Rajanna A, Ganapathi T, Suresh C,  Remedy of Targeting Cancer and Cancer Stem Cells with Botanicals, Springer, Singapore, Anticancer Plants: Mechanisms and Molecular Interactions,289-320, 2018.
  2. Suresh Challa, Rajanna Ajumeera, Naresh Venna, Phytoestrogens as a Natural Source for the Possible Colon Cancer Treatment, Springer, Singapore, Anticancer Plants: Mechanisms and Molecular Interactions, Pages: 259-281, 2018.
  3. Dhanasekaran M, Sandeep Kumar K,  Padmanav B, Rajanna A, Ravikumar R, Adipose derived stem cells in musculoskeletal disorders, Springer publication; Editor: Indumathi Somasundaram, Stem cell therapy for organ failure 2014, 143-149.
  4. Sing B K, Sharma RS, Rajanna A and Mathur AK; Electromagnetic fields in environment and itshealth hazards, International Conference on Recent Advances in Microwave Theory and Applications, Proceedings of the conference held on 21st-24th from November, 2008, Jaipur, P 558-560.
  5. Sharma R S, Rajanna A, Singh B K, Mathur A K and Mukherjee, Current status of development of RISUG: an intravasal mele contraceptive, Editors: R. S. Sharma, A.Rajanna, M. Rajalakshmi, Proceeding of the conference held on 19th-21st February, 2007, New Delhi.
Awards and Honors

1. Young Investigator Award-2014 from Department of Biotechnology(DBT), New Delhi, INDIA.

2. Best oral presentation award from 47th National conference Nutrition Society of India 9th -10th October 2015, National Institute of Nutrition (NIN), Hyderabad, India.