DR. G. BHANUPRAKASH REDDY,

Scientist ‘G’ & Head 
BIOCHEMISTRY


Email:   geereddy@yahoo.com
Email:  reddyg.bp@icmr.gov.in
Contact:  +91-40-27197252

Brief Profile

PhD in Biochemistry (Osmania University); Postdoctoral research at the Indian Institute of Science, Bengaluru and Case Western Reserve University, Cleveland-USA
Our research is focused on molecular nutrition of chronic non-communicable diseases (NCD) and age-related disorders- underlying basis of the disease, micronutrient-mediated molecular processes involved in NCD, and protective effect of functional foods and novel bioactive molecules. We also evaluate micronutrient status of adult and geriatric-groups and investigate the influence of nutrition on aging mechanisms including proteostasis and fibrotic mechanisms. Developed a raw-food based quantitative food frequency questionnaire to quantify dietary intakes. We reported the prevalence of micronutrient deficiencies, identified the factors associated with inadequacy of micronutrient intakes and revealed how deficiency of micronutrients impacts the molecular mechanisms in complications of diabetes and obesity. Our extensive work on protein glycation and aldoketo reductases under chronic hyperglycemia has led to the identification of novel bioactive molecules from functional foods against diabetic complications. Our studies provided new insights into the protein quality control mechanisms in chronic disorders and modulation of proteostatis mechanisms by nutritional factors.

Total Publications:234 (h-index:53; i10-index:144; citations: 8730) Selected publications in THE LAST 5 YEARS
  1. S Tattari, P Raghu, SM Gavaravarapu, N Bhatia, R Sarwal, H Rajkumar, GB Reddy. Nutritional requirements for the elderly in India: A status paper. Indian J Med Res. Sep 2022, 156: 411-420. DOI: 10.4103/ijmr.ijmr_2784_21. PMID: 36751740.
  2. D Kavitake, PB Devi, C Delattre, GB Reddy*, PH Shetty. Exopolysaccharides produced by an Enterococcus genus-An overview. Int J Biol Macromolecules. Jan 2023, 226: 111-120. PMID: 36493920.
  3. M Nagaraju, KK Kalahasti, PR Kallamadi, UR Addi, M. Satyavani, GB Reddy, SS Reddy. Anti-inflammatory effect of turmeric, amla, and black pepper mixture against sepsis-induced acute lung injury in rats. J Food Sci Technol 2023 Jan; 60(1): 252-261. PMID: 36349282.
  4. P Savitikadi, R Gogulothu, A Ismail, GB Reddy, VS Reddy. Combined prenatal to postnatal protein restriction augments protein quality control processes and proteolysis in the muscle of rat offspring. J Nutr Biochem 2023 Jan 18:109273. doi: 10.1016/j.jnutbio.2023.109273. PMID: 36681307.
  5. P Banerjee, GB Reddy, SM Gavaravarapu. Identifying opportunities and barriers for introducing a workplace nutrition and health program for employees: Findings from formative research. Work 2022 73: 1175–1187. PMID: 36093667.
  6. SS Reddy, UR Addi, R Pullakhandam, GB Reddy. Dietary zinc deficiency disrupts skeletal muscle proteostasis and mitochondrial biology in rats. Nutrition. 2022 Feb 9; 98:111625. doi: 10.1016/j.nut.2022.111625. PMID: 35439650
  7. R Pullakhandam, S Ghosh, B Kulkarni, GB Reddy, H Rajkumar, U Kapil, S Deb, AV Kurpad and HS. Sachdev. Reference cut-offs to define low serum zinc concentrations in healthy 1-19 year old Indian children and adolescents. Eur J Clin Nutr. 2022 Feb 9. doi: 10.1038/s41430-022-01088-4; PMID: 35140314
  8. Padakandla SR, Das T, Sai Prashanthi G, Angadi KK, Reddy SS, Reddy GB, Shivaji S. Gut mycobiome dysbiosis in rats showing retinal changes indicative of diabetic retinopathy. PLoS One. 2022 Apr 19;17(4): e0267080. PMID: 35439275
  9. UR Addi, S Jakhotia, SS Reddy, GB Reddy. Advanced glycation end products in brain aging. Chem Biol Interact. 2022 Mar 1;355: 109840. doi: 10.1016/j.cbi.2022.109840. PMID: 35104490
  10. CU Kumar, P Suryanarayana, SS Reddy, MA Patil, PM Chary, PU Kumar, GB Reddy. Protective effect of cinnamon on diabetic cardiomyopathy in nicotinamide-streptozotocin induced diabetic rat model. J Diabetes Metab Disord (2022). https://doi.org/10.1007/s40200-021-00948-3.
  11. GB Reddy, S Tattari, S Ghosh, R Pullakhandam, NB Kumar, B Kulkarni, A Laxmaiah, U Kapil, S. Deb, R Hemalatha, AV Kurpad, HS Sachdev. Prevalence of vitamin A deficiency and dietary inadequacy in Indian school-age children and adolescents. Eur J Nutr. 2022 Feb;61(1):197-209. PMID: 34251518
  12. S Rajagopal, A Gupta, R Parveen, N Shukla, S Bhattacharya, J Naravula, SA Kumar S, P Mathur, A Simlot, S Mehta, C Bihari, S Mehta, AK Mishra, KM Medicherla, GB Reddy, N Sreenivasulu, PBK Kishor and P Suravajhala. Vitamin K in human health and metabolism: A nutrigenomics review. Trends Food Sci. 2022 Jan; 119: 412–427.
  13. P Savitikadi, R Pullakhandam, B Kulkarni, BN Kumar, GB Reddy, VS Reddy. Chronic effects of maternal low-protein and low-quality protein diets on body composition, glucose-homeostasis and metabolic factors, followed by reversible changes upon rehabilitation in adult rat offspring. Nutrients 2021 Nov 18; 13 (11): 4129. doi: 10.3390/nu13114129. PMID: 34172268
  14. GB Reddy, R Pullakhandam, T Shalini, B Kulkarni, HS Sachdev, AV Kurpad. Vitamin A supplementation and fortification programs in India: need for review. NFI Bullet. 2021 Oct; 4 (4):1-8
  15. Kurpad AV, Ghosh S, Thomas T, Bandyopadhyay S, Goswami R, Gupta A, Gupta P, John AT, Kapil U, Kulkarni B, Kuriyan R, Madan J, Makkar S, Nair KM, Pullakhandam R, Reddy GB, Shah D, Sachdev HS. Perspective: When the cure might become the malady: the layering of multiple interventions with mandatory micronutrient fortification of foods in India. Am J Clin Nutr. 2021 Jul 28:nqab245. doi: 10.1093/ajcn/nqab245. PMID: 34320172
  16. KS Vimaleswaran, GB Reddy. Letter to the Editor on Guiding global best practice in personalized nutrition based on genetics: The development of a nutrigenomics care map. J Acad Nutr Diet. 2021 July. 121(7); 1215-1216
  17. B Kulkarni, R Peter, S Ghosh, R Pullakhandam, T Thomas, GB Reddy, H Rajkumar, U Kapil, S Deb, R Johnston, PK Agrawal, AD Wagt, AV Kurpad, HS Sachdev. Prevalence of iron deficiency and its socio-demographic patterning in Indian children and adolescents: findings from Comprehensive National Nutrition Survey. J Nutr. 2021 May 28:nxab145. doi:10.1093/jn/nxab145. PMID: 34049401.
  18. T Shalini, SS Jose, PS Prasanthi, N Balakrishna, K Viswanath, GB Reddy. Carotenoid status in patients with type 2 diabetes with and without retinopathy. Food Function 2021 May 21;12(10):4402-4410. PMID: 33928954
  19. R Pullakhandam, PK Agrawal, R Peter, S Ghosh, GB Reddy, B Kulkarni, T Thomas, AV Kurpad, HS Sachdev, A Porwal, N Khan, S Ramesh, R Acharya, A Sarna, U Kapil, H Rajkumar, AD Wagt, S Deb, R Johnston. Biochemical zinc deficiency in Indian children and adolescents: Findings from the Comprehensive National Nutrition Survey 2016-18. Am J Clin Nutr 2021 Apr 8:nqab066. doi: 10.1093/ajcn/nqab066. PMID: 33831945
  20. VS Reddy, S Pandarinath, M Archana, GB Reddy. Impact of chronic hyperglycemia on small heat shock proteins in diabetic rat brain. Arch Biochem Biophys. 2021 Apr 15; 701:108816. PMID: 33631184
  21. GB Reddy, R Pullakhandam, S Ghosh, N Boiroju, S Tattari, A Laxmaiah, R Hemalatha, U Kapil, HS Sachdev, AV Kurpad. Vitamin A deficiency among under-five year children in India: an analysis of national data sets to reflect on the need for vitamin A supplementation. Am J Clin Nutr. 2021 Apr 6;113(4):939-947. doi: 10.1093/ajcn/nqaa314. PMID: 33330941
  22. PS Chitra, D Chaki, TR Mokalla, AK Gadde, SG Agraharam, GB Reddy. Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes. Exp Eye Res 2020 Nov; 200:108230. PMID:32931824.
  23. Kollati Y, Akella RRD, Naushad SM, Borkar D, Thalla M, Nagalingam S, Lingappa L, Patel RK, Reddy GB, Dirisala VR. Newborn screening and single nucleotide variation profiling of TSHR, TPO, TG and DUOX2 candidate genes for congenital hypothyroidism. Mol Biol Rep. 2020 Sep 15. doi: 10.1007/s11033-020-05803-x. PMID:32930933.
  24. Kasam, S Ghandikota, D Soundararajan, GB. Reddy, SK. Huang, AG. Jegga, SK. Madala. Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis. EMBO Molecular Medicine. 2020 Sep; 12(9): e12131; PMID: 32761869
  25. Shalini, PS Chitra, BN Kumar, G Madhavi, GB Reddy. Frailty and nutritional status among urban older adults in South India. J Aging Res, 2020 July; 2020: 8763413. PMID: 32695510
  26. R Nishad, P Meshram, AK Singh, GB Reddy, AK Pasupulati. Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria. BMJ Open Diabetes Research & Care, 2020 Jun; 8(1): e001203. PMID: 32601154.
  27. SS Reddy, YK Prabhakar, CU Kumar, PY Reddy, GB Reddy. Effect of vitamin-B12 supplementation on retinal lesions in diabetic rats. Molecular Vision 2020, 26:311-325. PMID: 32355441
  28. G Praveen, T Shalini, M Sivaprasad, GB Reddy. Relative telomere length and mitochondrial DNA copy number with age: Association with plasma folate and vitamin B12. Mitochondrion. 2020 Jan; 51: 79-87. PMID: 31935457
  29. KK Godisela, SS Reddy, PY Reddy, CU Kumar, VS Reddy, R Ayyagari, GB Reddy. Sorbitol-mediated cellular stress response in obesity-associated retinal degeneration. Arch Biochem Biophys. 2020 Jan 15; 679:108207. PMID: 31760123
  30. RP Kshirsagar, AA Kulkarni, RS Chouthe, SK Pathan, HD Une, GB Reddy, PV Diwan, SA Ansari, JN Sangshetti. SGLT inhibitors as antidiabetic agents: a comprehensive review. RSC Advances, 2020; 10: 1733-1756. doi.org/10.1039/C9RA08706K.
  31. Reddy VS, Trinath J, Reddy GB. Implication of homocysteine in protein quality control processes. Biochemie. 2019 Jun 30. 165:19-31. PMID: 31269461
  32. RK Kasam, GB Reddy, AG Jegga, SK Madala. Dysregulation of mesenchymal cell survival pathways in severe fibrotic lung disease: The effect of nintedanib therapy. Front Pharmacol 2019; 10: 532. PMID: 31156440
  33. Sivaprasad M, Shalini T, Reddy PY, Seshacharyulu M, Madhavi G, Kumar BN, Reddy GB. Prevalence of vitamin deficiencies in the apparently healthy urban adult population: assessed by sub-clinical status and dietary intakes. Nutrition 2019 July-Aug; 63-64:106-113. PMID: 30954757
  34. Reddy SS, Shruthi K, Joy D, Reddy GB. 4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system. Chem Biol Interact 2019 June; 306: 70-77. PMID: 30980806.
  35. Shalini T, Sivaprasad M, Balakrishna M, Madhavi G, Radhika MS, Pullakhandam R, Reddy GB. Micronutrient intakes and status assessed by probability approach among the urban adult population of Hyderabad city in South India. Eur J Nutr. 2019 Dec;58(8):3147-3159. PMID: 30511165.
  36. Reddy VS, Ravindranath P, Ismail I, Pullakhandam R, Reddy GB. Nutrigenomics: Opportunities & challenges for public health nutrition (Invited Review). Indian J Med Res (Special Issue: Nutrition Research) 2018 Nov;148(5):632-641. PMID: 30666988
  37. Sontake V, Kasam RK, Sinner D, Reddy GB, White ES, Jegga AG, Madala SK. Wilms’ Tumor-1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease. JCI-Insight 2018; 3(16):e121252.
  38. Mahaling B, Srinivasarao DA, Raghu G, Kasam R, Reddy GB, Katti DS. A non-invasive nanoparticle mediated delivery of triamcinolone acetonide ameliorates diabetic retinopathy in rats. Nanoscale 2018 Sep;10:16485-16498. PMID: 29897081
  39. Jakhotia S, Sivaprasad M, Shalini T, Reddy PY, Viswanath K, Jakhotia K, Sahay R, Sahay M, Reddy GB. Circulating levels of Hsp27 in microvascular complications of diabetes: Prospects as a biomarker of diabetic nephropathy. J Diabetes Complications. 2018 Feb; 32(2): 221-225. PMID: 29175119
  40. Reddy SS, Shruthi K, Prabhakar YK, Sailaja G, Reddy GB. Implication of altered ubiquitin-proteasome system and ER stress in the muscle atrophy of diabetic rats. Arch Biochem Biophys 2018. 639: 16-25. PMID: 29277369
  41. Jose SS, Shalini T, Balakrishna N, Radhika MS, Brahmam GNV, Reddy GB. Validity and reproducibility of a raw food based quantitative food frequency questionnaire (RFQNFFQ) across three seasons among urban adults of South India. Indian J Dietetics Nutr 2018; 55(1):1-17. DOI:10.21048/ijnd.2018.55.1.18269
Books and book chapters in the LAST 5 YEARS
  1. G Praveen, M Sivaprasad, GB Reddy. Telomere length and vitamin B12. In Vitamins and Hormones, Vol 119: Vitamin B12 (Ed: Gerald Litwack), March 2022, Elsevier. doi: 10.1016/bs.vh.2022.01.014. Epub 2022 Feb 25. PMID: 35337624
  2. VS Reddy, J Trinath J, GB Reddy. Small heat shock proteins in inflammatory diseases. in Heat Shock Proteins in Inflammatory Diseases - Heat Shock Proteins-22 (Eds: AAA Asea and P Kaur). 2020; Springer https://doi.org/10.1007/7515_2020_9.
  3. SS Reddy, GB, Reddy and K Krishnaswamy. Case studies on functional foods-Health benefits of turmeric (Curcumin longa Linn). In: Functional Foods Monographs 2017. ILSI Southeast Asia Region Monograph Series, 2018, pp 32-27.
Awards and recognitions
  1. Fellow, International Union of Nutritional Sciences-2022
  2. Fellow, National Academy of Medical Sciences - 2020
  3. Fellow, Royal Society of Chemistry (London, UK) - 2019
  4. Fellow, Telangana Academy of Sciences, India – 2015
  5. Fellow, AP Akademi of Sciences, India – 2012
  6. Fellow, National Academy of Sciences, India - 2006
  7. Bireswar Chakraborty Oration by ARVO-India Chapter, 2019
  8. ICMR-Basanti Devi Amir Chand Prize – 2010
  9. Scopus India Young Scientist Award (Medicine) – 2008
  10. ICMR Dr. V. N. Patwardhan Prize – 2002