DR. G. BHANUPRAKASH REDDY,

Scientist ‘G’ & Head 
BIOCHEMISTRY


Email:   geereddy@yahoo.com
Email:  reddyg.bp@icmr.gov.in
Contact:  +91-40-27197252

Brief Profile

PhD (Biochemistry) from Osmania University. Postdoctoral research at the Indian Institute of Science, Bengaluru and Case Western Reserve University, Cleveland-USA. Research focus is on molecular nutrition of age-related diseases: Evaluate nutritional status of elderly as well people with age-related diseases to understand the influence of nutrients, particularly micronutrients on molecular mechanisms related to age-related diseases. Developed a raw-food based quantitative food frequency questionnaire to quantify dietary intakes. Assessed the prevalence of subclinical micronutrient deficiencies and identified factors associated with adequacy of micronutrient intakes in adults. Studies revealed a role for micronutrients in the development of diabetic complications and provided the basis for the influence of micronutrients on molecular processes involved in diabetic complications. We reported a decline in telomere length (TL) and mitochondrial DNA copy number (mtCN) with age in the Indian population and folate and vitamin B12 may delay aging by preventing the reduction in TL length and mtCN. We work with suitable animal models for studying the disease biology of complications of diabetes and obesity and to understand the role of nutrition. Described age-related eye diseases- neuronal and retinal degeneration and cataract, in a spontaneous obese rat model. These studies suggested that sorbitol could be a molecular link between metabolic syndrome and age-related diseases. Investigated the impact of functional foods and their bioactive molecules on signaling mechanisms involved in age-related diseases. The pioneering work on involvement protein glycation and aldo-keto reductases under chronic hyperglycemia, paved the way for exploring functional foods molecules as aldose reductase inhibitors (ARI) and antiglycating agents (AGA). Further, isolated and characterized novel compounds from functional foods as ARI and AGA for combating diabetic complications. Our works is aimed to understand the role of protein quality control (PQC) machinery in age-related diseases including neurodegenerative disorders as well as to understand the modulation of PQC by nutritional and dietary means.
Total Publications:180 (Total Impact Factor: 675; h-index:45)
  1. G Praveen, T Shalini, M Sivaprasad, GB Reddy. Relative telomere length and mitochondrial DNA copy number with age: Association with plasma folate and vitamin B12. Mitochondrion. 2020 Jan; 51: 79-87. PMID: 31935457
  2. KK Godisela, SS Reddy, PY Reddy, CU Kumar, VS Reddy, R Ayyagari, GB Reddy. Sorbitol-mediated cellular stress response in obesity-associated retinal degeneration. Arch Biochem Biophys. 2020 Jan 15; 679:108207. PMID: 31760123
  3. RP Kshirsagar, AA Kulkarni, RS Chouthe, SK Pathan, HD Une, GB Reddy, PV Diwan, SA Ansari, JN Sangshetti. SGLT inhibitors as antidiabetic agents: a comprehensive review. RSC Advances, 2020; 10: 1733-1756. doi.org/10.1039/C9RA08706K
  4. Dave VP. Susaimanickam PJ, Mir IA, Mariappan I, Basu S, Reddy BG, Pappuru RR, Jalali S, Das T. Learning curve of a trained vitreo-retinal surgeon in sub-retinal injections in a rat model: Implications for future clinical trials. Indian J Ophthalmol. 2019 Sep;67(9):1455-1458. PMID: 31436191.
  5. Reddy VS, Trinath J, Reddy GB. Implication of homocysteine in protein quality control processes. Biochemie. 2019 Jun 30. 165:19-31. PMID: 31269461
  6. Srinivasarao DA, Reddy SS, Reddy GB, Katti DS. Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract. Int J Pharm 2019 Sep 10;568:118474. doi: 10.1016/j.ijpharm.2019.118474. PMID: 31279055
  7. Reddy MR, Aidhen IS, Reddy UB and Reddy GB, Ingle K, Mukhopadhyay S. Synthesis of 4-c--d-glucosylated isoliquiritigenin and analogues as aldose reductase inhibitors. Eur J Org Chem 2019 June; 2019 (24): 3937-3948
  8. RK Kasam, GB Reddy, AG Jegga, SK Madala. Dysregulation of mesenchymal cell survival pathways in severe fibrotic lung disease: The effect of nintedanib therapy. Front Pharmacol 2019; 10: 532. PMID: 31156440
  9. Sivaprasad M, Shalini T, Reddy PY, Seshacharyulu M, Madhavi G, Kumar BN, Reddy GB. Prevalence of vitamin deficiencies in the apparently healthy urban adult population: assessed by sub-clinical status and dietary intakes. Nutrition 2019 July-Aug; 63-64:106-113. PMID: 30954757
  10. Reddy SS, Shruthi K, Joy D, Reddy GB. 4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system. Chem Biol Interact 2019 June; 306: 70-77. PMID: 30980806.
  11. Shalini T, Sivaprasad M, Balakrishna M, Madhavi G, Radhika MS, Pullakhandam R, Reddy GB. Micronutrient intakes and status assessed by probability approach among the urban adult population of Hyderabad city in South India. Eur J Nutr, 2018 Dec 3; PMID: 30511165 https://doi.org/10.1007/s00394-018-1870-3
  12. Shruthi K, Reddy SS, Chitra PS, Reddy GB. Ubiquitin‐proteasome system and ER stress in the brain of diabetic rats. J Cell Biochem. 2019 Apr;120 (4): 5962-5972.PMID: 30317658.
  13. Reddy VS, Ravindranath P, Ismail I, Pullakhandam R, Reddy GB. Nutrigenomics: Opportunities & challenges for public health nutrition (Invited Review). Indian J Med Res (Special Issue: Nutrition Research) 2018 Nov;148(5):632-641. PMID: 30666988
  14. Sontake V, Kasam RK, Sinner D, Reddy GB, White ES, Jegga AG, Madala SK. Wilms’ Tumor-1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease. JCI-Insight 2018; 3(16):e121252.
  15. Kishore TK, Baba AB, Kowshik J. Reddy GB, Nagini S. Gedunin, a neem limonoid in combination with epalrestat inhibits cancer hallmarks by attenuating aldose reductase-driven oncogenic signaling in SCC131 oral cancer cells. Anticancer Agents Med Chem 2018;18(14):2042-2052. PMID: 30062975
  16. Mahaling B, Srinivasarao DA, Raghu G, Kasam R, Reddy GB, Katti DS. A non-invasive nanoparticle mediated delivery of triamcinolone acetonide ameliorates diabetic retinopathy in rats. Nanoscale 2018 Sep 13;10(35):16485-16498. PMID: 29897081
  17. Gopalakrishnan S, Ediga HH, Reddy SS, Reddy GB*, A Ismail. Procyanidin-B2 enriched fraction of cinnamon acts as a proteasome inhibitor and anti-proliferative agent in human prostate cancer cells. IUBMB Life. 2018. May;70(5):445-457. PMID: 29537730
  18. Thangella PAV, Pasumarti SNBS, Pullakhandam R, Reddy GB, Daggu MR. Differential expression of leaf proteins in four cultivars of peanut (Arachis hypogaea L) under water stress. 3D Biotech. 2018 Mar; 8(3):157; PMID: 29515963
  19. Reddy VS, Trinath J, Madala SK, Reddy GB. Extracellular small heat shock proteins: exosomal biogenesis and function. Cell Stress Chaperones. 2018 May; 23(3):441-454. PMID: 29086335
  20. Jakhotia S, Sivaprasad M, Shalini T, Reddy PY, Viswanath K, Jakhotia K, Sahay R, Sahay M, Reddy GB. Circulating levels of Hsp27 in microvascular complications of diabetes: Prospects as a biomarker of diabetic nephropathy. J Diabetes Complications. 2018 Feb; 32(2): 221-225. PMID: 29175119
  21. Reddy SS, Shruthi K, Prabhakar YK, Sailaja G, Reddy GB. Implication of altered ubiquitin-proteasome system and ER stress in the muscle atrophy of diabetic rats. Arch Biochem Biophys 2018. 639: 16-25. PMID: 29277369
  22. Jose SS, Shalini T, Balakrishna N, Radhika MS, Brahmam GNV, Reddy GB. Validity and reproducibility of a raw food based quantitative food frequency questionnaire (RFQNFFQ) across three seasons among urban adults of South India. Indian J Dietetics Nutr 2018; 55(1):1-17. DOI:10.21048/ijnd.2018.55.1.18269 
  23. Reddy MR, Aidhen IS, Karnam S and Reddy GB. Synthesis of C-analogues of β-glucogallin and aldose reductase inhibition studies. Eur J Org Chem. 2017 Dec 29; 2017 (48): 7283–7294
  24. Singh S, Geddam JJ, Reddy GB, Pallepogula DR, HB Pant, SB Neogi, N John, SR Kolli, Doyle P, Kinra S, Ness A, Murthy GVS. Folate, vitamin B12, ferritin and haemoglobin levels among women of childbearing age from a rural district in South India. BMC Nutrition 2017; 3:50
  25. Raghu G, Akileshwari C, Reddy VS, Reddy GB. Attenuation of diabetic retinopathy in rats by ellagic acid through inhibition of AGE formation. J Food Sci Technol 2017. 54:2411–21. PMID: 28740299
  26. Shruthi K, Reddy SS, Reddy GB. Altered ubiquitin-proteasome system and declined autophagy leads to apoptosis in diabetic rat retina. Arch Biochem Biophys 2017; 627:10-20. PMID: 28606465
  27. Susaimanickam PJ, Maddileti S, Kumar V, Boyinpally SR, Naik RR, Naik MN, Reddy GB, Sangwan VS, Mariappan I. Generating minicorneal organoids from human induced pluripotent stem cells. Development. 2017 May 30; 144: 2338-2351 PMID: 28559289
  28. Godisela KK, Reddy SS, Kumar CU, Reddy PY, Jablonski MM, Ayyagar A, Reddy GB. Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome Mol Vis 2017; 23:263-274. PMID: 28465658
  29. Sontake V, Wang Y, Kasam RK, Reddy GB, Sinner D, Naren AP, McCormack FX, White ES, Jegga AG, Madala SK. Hsp90 regulation of fibroblast activation in pulmonary fibrosis. J Clin Invest-Insight 2017 Feb 23; 2(4):e91454. PMID: 28239659
  30. Reddy GB, Reddy PY, Surolia A. Alzheimer’s and Danish Dementia peptides induce cataract and perturb retinal architecture in rats. BioMol Concepts 2017 Mar; 8(1):45-84. PMID: 28222009
  31. Saravanan N, Patil MA, Kumar PU, Suryanarayana P, Reddy GB. Dietary ginger improves glucose dysregulation in a long term high fat high fructose fed prediabetic rat model. Indian J Exp Biol 2017 March; 55:142-150
  32. Reddy KA, Kuamr PU, Srinivasulu M, Triveni B, Sharada K, Ismail A, Reddy GB. Overexpression and enhanced specific activty of aldoketo reductases (AKR1B1 & AKR1B10) in human breast tumors. The Breast 2017 February; 31:137-143. PMID: 27855345
  33. Sivaprasad M, Shalini T, Das S, Vijayalakshmi V, Reddy GB. Vitamins B6, folic acid and B12: molecular functions and prevalence of deficiency in India. Proc Indian Natn Sci Acad Dec 2016. 82(5):1381-1394.
  34. Shalini T, Sivaprasad M, Ismail A, Reddy GB. Emerging problem of vitamin D deficiency in India. Proc Indian Natn Sci Acad Dec 2016. 82(5):1395-1412.
  35. Pasupulati AK, Chitra PS, Reddy GB. Advanced glycation endproducts mediated cellular and molecular events in the pathology of diabetic nephropathy. BioMol Concepts 2016 Dec 1; 7(5-6):293-309. PMID: 27816946
  36. Chettu SK, RB Madhu, GB Raolji, KR Babu, NSK Rao, S Gopalakrishnan, A Ismail, Reddy GB, Shafi S. First total synthesis of cyclodepsipeptides clavatustide A and B and their enantiomers. RSC Advances. 2016. 6: 61555-61665. DOI: 10.1039/C6RA08861A.
  37. Noolu B, Bhat M, Qadri SS, Reddy VS, Reddy GB, Ismail A. In vivo inhibition of proteasome activity and tumor growth by Murraya koenigii leaf extract in breast cancer xenografts. Anticancer Agents Med Chem. 2016, 1605-1614. PMID: 27198988
  38. Biswas P, Chavali VRM, G Agnello, E Stone, C Chakarova, JL Duncan, C6Kannabiran, M Homsher, SS Bhattacharya, MA Naeem, A Kimchi, D Sharon, T Iwata, S Riazuddin, Reddy GB, JF Hejtmancik, G Gerogiou, SA Riazuddin, Ayyagari R. A missense mutation in the ASRGL1 gene is involved in causing autosomal recessive retinal degeneration. Hum Mol Genet 2016; 25:2483-2497. PMID: 27106100
  39. Shruthi K, Reddy SS, Reddy PY, Sivalingam P, Harishankar N, Reddy GB. Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. J Nutr Biochem 2016.33:73-81.PMID: 27260470
  40. Raghu G, Jakhotia S, Kuamr PA, Reddy GB. Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats. Food & Function, 2016; 7: 1574-83. PMID:26902315
  41. Yaseen Y, H Pushpalatha, Reddy GB, S Ovais, P Rathore,  M Samim, M Akthar, KC Sharma, S Shafi, S Singh, K Javed. Design and synthesis of pyridazinone substituted benzenesulfonylurea derivatives as antihyperglycaemic agents and inhibitors of aldose reductase-an enzyme embroiled in diabetic complications. J Enzyme Inhib Med Chem 2016 Dec;31(6):1415-27. PMID: 26879420
  42. Kesavan R, S Upadhyay, R Bendre, S Chandel, G Raghu, PU Rani, H Giri, G Sahu, PU Kumar, Reddy GB, G Joksic, AK Bera, M Dixit. Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. Nutr Metab Cardiovasc Dis, 2016 Apr; 26(4):293-301. PMID: 26868432
  43. Sivaprasad M, Shalini T, Balakrishna N, Sudarshan M, Lopamudra P, Suryanarayana P, Arlappa N, Ravikumar BP, Radhika MS, Reddy GB. Status of vitamin B12 and folate among the urban adult population in South India. Ann Nutr Metab 2016; 68(2):94-102. PMID: 26667891
  44. Kumar PA, Welsh G, Raghu, Saleem M, Reddy GB. Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2:  Implications for podocyte depletion and proteinuria in diabetes. Arch Biochem Biophys 2016 Jan 15; 590:10-19. PMID: 26550927
  45. Reddy VS, Reddy GB. Role of crystallins diabetic complications. Biochem Biophys Acta-General Subjects 2016; 1860:269-277. PMID: 25988654
  46. Duncan JL, Biswas P, Kozak I, Navani M, Syed R, Soudry S, Menghini M, Caruso RC, Jeffrey BG, Heckenlively JR, Reddy GB, Lee P, Roorda A, Ayyagari R. Ocular phenotype of a family with FAM161A-associated retinal degeneration. Ophthalmic Genet. 2016 Mar;37(1):44-52. PMID:25007332
  47. Kishore TK, Ganugula R, Gade D, Reddy GB, Nagini S. Gedunin abrogates aldose reductase, PI3K/Akt/mToR and NF-kB signaling pathways to inhibit angiogenesis in a hamster model of oral carcinogenesis. Tumour Biol. 2016 Feb;37(2):2083-93. PMID: 26342697       
  48. Sontake V, Shanmukhappa SK, DiPasquale BA, Reddy GB, Medvedovic M, Hardie WD, White ES, Madala SK. Fibrocytes regulate Wilms Tumor 1-positive cell accumulation in severe fibrotic lung disease. J Immunol. 2015;195(8):3978-91; PMID: 26371248
  49. Deshpande J, Shankaranarayanan J, Bhanuprakash RG, Sreenivasa RS, Juturu V. Soluble curcumin in the prevention of diabetic retinopathy via modulation of antioxidant activity and genetic pathways-in vivo model. Adv Ophthalmol Vis Syst. 2015; 3(1): 00077.
  50. Reddy GB, Sivaprasad M, Shalini T, Satyanarayana A, Seshacharyulu M, Balakrishna N, Viswanath K, Sahay M. Plasma vitamin D status in type 2 diabetes patients with and without retinopathy. Nutrition, 2015; 31(7-8):959-63. PMID: 26059368
  51. Reddy VS, Jakhotia S, Reddy PY, Reddy GB. Hyperglycemia induced expression, phosphorylation, and translocation of αB-crystallin in rat skeletal muscle. IUBMB Life. 2015 Apr. 67(4):291-299. PMID: 25900025
  52. Kshirsagar RP, Kothamasu, MV, Patil MA, Nimbulkar C, Reddy GB, Kumar BD, Bakshi V, Diwan PV. Geranium oil ameliorates endothelial dysfunction in high-fat high sucrose diet-induced metabolic complications in rats. J Func Foods 2015; 15:284-293.
  53. Chitra PS, Swathi T, Sahay R, Reddy GB*, Menon RK, Kumar PA. Growth hormone induces transforming growth factor-beta-induced protein in podocytes: Implications for podocyte depletion and proteinuria. J Cell Biochem, 2015; 116:1947-56. PMID: 25740786.
  54. Shrivastava S, Jeengar MK, Reddy VS, Reddy GB, VG Naidu (2015) Anticancer effects of celastrol on human triple negative breast cancer: Possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways. Exp Mol Pathol 2015; 98:313-327; PMID: 25818165
  55. Reddy VS and Reddy GB. Emerging role for αB-crystallin as a therapeutic agent: Pros and cons. Curr Mol Med 2015; 15 (1):47-61. PMID: 25601468
  56. Snow A, Shieh B, Chang KC, Pal A, Lenhart P, Ammar D, Ruzycki P, Palla S, Reddy GB, Petrash JM. Aldose reductase expression as a risk factor for cataract. Chem Biol Interact 2015 June 5; 234:247-253. PMID: 25541468
  57. Palika R, Mashurabad PC, Nair MK, Reddy GB, Pullakhandam R. Characterization of iron binding phosphopeptide released by gastrointestinal digestion of egg white. Food Res International. 2015; 67: 308-14
  58. Jose SS, Radhika MS, Balakrishna N, Brahmam GNV, Reddy GB. Development of a raw food based quantitative food frequency questionnaire and evaluation of its validity and reproducibility among urban individuals of Hyderabad, India. International J Food Nutr Sci 2014; 3(6): 180-187
  59. Pavithra N, Sathish L, Suneel Kumar A, Venkatarathanamma V, Pushpalatha H, Reddy GB and Ananda K. In-vitro studies on α-amylase, α-glucosidase and aldose reductase inhibitors found in endophytic fungi isolated from Ocimum sanctum. Current Enzyme Inhibition, 2014, 10(2), 129-136.
  60. Patil MA, Suryanarayana P, Putcha UK, Srinivas M, Reddy GB. Evaluation of neonatal streptozotocin-induced diabetic rat model for the development of cataract. Oxid Med Cell Longev. 2014; 2014:463264. PMID: 25505935
  61. Muthenna P, Raghu G, Kumar PA, Surekha MV, Reddy GB. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chem Biol Interact. 2014 Sep 6; 222C:68-76. PMID: 25199697
  62. Kowshik J, Giri H, Kishore TK, Kesavan R, Vankudavath RN, Reddy GB, Dixit M, Nagini S. Ellagic acid inhibits VEGF/VEGFR2, PI3K/Akt and MAPK signaling cascades in the hamster cheek pouch carcinogenesis model. Anticancer Agents Med Chem. 2014; 14(9):1249-60. PMID: 25060902
  63. Reddy VS, Kumar ChU, Raghu G, Reddy GB. Expression and induction of small heat shock proteins in rat heart under chronic hyperglycemic conditions. Arch Biochem Biophys. 2014 Sep 15; 558:1-9. PMID:24950024
  64. Reddy SS, Shruthi K, Reddy VS, Raghu G, Suryanarayana P, Giridharan NV, Reddy GB. Altered ubiquitin-proteasome system leads to neuronal cell death in a spontaneous obese rat model. Biochim Biophys Acta-General Subjects. 2014 Sep; 1840(9):2924-34. PMID: 24949983
  65. Ovais S, Pushpalatha H, Reddy GB, Rathore P, Bashir R, Yaseen S, Dheyaa A, Yaseen R, Tanwar O, Akthar M, Samim M, Javed K. Synthesis and biological evaluation of some new pyrazoline substituted benzenesulfonylurea/ thiourea derivatives as anti-hyperglycaemic agents and aldose reductase inhibitors. Eur J Med Chem. 2014 Jun 10; 80:209-17. PMID: 24780598
  66. Reddy VS, Kumar CU, Reddy GB. Effect of chronic hyperglycemia on crystallin levels in rat lens. Biochem Biophys Res Commun. 2014 Apr 4; 446(2):602-7. PMID: 24632206
  67. Shrivastava S, Kulkarni P, Thummuri D, Jeengar MK, Naidu VG, Alvala M, Reddy GB, Ramakrishna, S. Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells. Apoptosis. 2014; 19:1148-164. PMID: 24729100
  68. Venkanna A, Siva B, Poornima B, Vadaparthi PR, Prasad KR, Reddy KA, Reddy GB, Babu KS. Phytochemical investigation of sesquiterpenes from the fruits of Schisandra chinensis and their cytotoxic activity. Fitoterapia. 2014; 95:102-8. PMID: 24631765.
  69. Akileshwari C, Raghu G, Muthenna P, Suryanaryana P, Mueller NH, Petrash JM, Reddy GB. Bioflavonoid ellagic acid inhibits aldose reductase: implications for prevention of diabetic complications. 2014; J Func Foods 6: 374-383.
  70. Reddy VS, Raghu G, Reddy SS, Pasupulati AK, Suryanarayana P, Reddy GB. Response of small heat shock proteins in diabetic rat retina. Invest Ophthalmol Vis Sci. 2013; 54(12):7674-82. PMID: 24159092
  71. Grama CN, Suryanarayana P, Patil MA, Raghu G, Balakrishna N, Kumar MN, Reddy GB. Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PLoS One. 2013 Oct 14; 8(10):e78217. PMID: 24155984
  72. Muthenna P, Raghu G, Akileshwari C, Sinha SN, Suryanarayana P, Reddy GB. Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. IUBMB Life. 2013 Nov; 65(11):941-50. PMID: 24136906
  73. Pasupulati AK, Reddy GB. Nutrition & metabolic syndrome. Rev Endocr Metab Disord. 2013 Sep; 14(3):217. PMID: 24052338
  74. Kumar PA, Chitra PS, Reddy GB. Metabolic syndrome and associated chronic kidney diseases: nutritional interventions. Rev Endocr Metab Disord. 2013 Sep; 14(3):273-86. PMID: 24036690
  75. Rajkumar S, Vasavada AR, Praveen MR, Ananthan R, Reddy GB, Tripathi H, Ganatra DA, Arora AI, Patel AR. Exploration of molecular factors impairing superoxide dismutase isoforms activity in human senile cataractous lenses. Invest Ophthalmol Vis Sci. 2013 Sep 17; 54(9):6224-33. PMID: 23970468
  76. Rani UP, Kesavan R, Ganugula R, Avaneesh T, Kumar UP, Reddy GB, Dixit M. Ellagic acid inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and prevents atheroma formation in streptozotocin-induced diabetic rats. J Nutr Biochem. 2013 Nov; 24(11):1830-9. PMID: 23866995
  77. Reddy PY, Giridharan NV, Balakrishna N, Validandi V, Pullakhandam R, Reddy GB. Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol. IUBMB Life. 2013 May; 65(5):472-8. PMID: 23504868
  78. Balakumar M, Saravanan N, Prabhu D, Regin B, Reddy GB, Mohan V, Rema M, Balasubramanyam M. Benefits of early glycemic control by insulin on sensory neuropathy and cataract in diabetic rats. Indian J Exp Biol. 2013 Jan; 51(1):56-64. PMID: 23441480
  79. Cukras C, Gaasterland T, Lee P, Gudiseva HV, Chavali VR, Pullakhandam R, Maranhao B, Edsall L, Soares S, Reddy GB, Sieving PA, Ayyagari R. Exome analysis identified a novel mutation in the RBP4 gene in a consanguineous pedigree with retinal dystrophy and developmental abnormalities. PLoS One. 2012; 7(11):e50205. PMID: 23189188
  80. Pullakhandam R, Palika R, Ghosh S, Reddy GB. Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: the significance of transthyretin. IUBMB Life. 2012; 64: 975-82. PMID: 23129325
  81. Rao VR, Muthenna P, Shankaraiah G, Akileshwari C, Babu KH, Suresh G, Babu KS, Chandra Kumar RS, Prasad KR, Yadav PA, Petrash JM, Reddy GB*, Rao JM. Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors. Eur J Med Chem. 2012; 57:344-61. PMID: 23124161
  82. Tiruvalluru M, Ananthathmakula P, Ayyalasomayajula V, Nappanveettil G, Ayyagari R, Reddy GB. Vitamin A supplementation ameliorates obesity-associated retinal degeneration in WNIN/Ob rats. Nutrition. 2013; 29(1): 298-304. PMID: 23036575
  83. Akileshwari C, Muthenna P, Nastasijević B, Joksić G, Petrash JM, Reddy GB. Inhibition of aldose reductase by Gentiana lutea extracts. Exp Diabetes Res. 2012; 2012:147965. PMID: 22844269
  84. Puppala M, Ponder J, Suryanarayana P, Reddy GB, Petrash JM, LaBarbera DV. The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis. PLoS One. 2012; 7(4):e31399. PMID: 22485126
  85. Sireesha R, Laxmi SG, Mamata M, Reddy PY, Goud PU, Rao PV, Reddy GB, Vishnupriya S, Padma T. Total activity of glutathione-S-transferase (GST) and polymorphisms of GSTM1 and GSTT1 genes conferring risk for the development of age-related cataracts. Exp Eye Res. 2012 May; 98:67-74. PMID: 22446016
  86. Reddy PY, Giridharan NV, Reddy GB. Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats. Mol Vis. 2012; 18:495-503. PMID: 22393276
  87. Muthenna P, Akileshwari C, Saraswat M, Bhanuprakash Reddy G. Inhibition of advanced glycation end-product formation on eye lens protein by rutin. Br J Nutr. 2012; 107(7):941-9. PMID: 21864418
  88. Reddy GB, Muthenna P, Akileshwari C, Saraswat M, Petrash JM. Inhibition of aldose reductase and sorbitol accumulation by dietary rutin. Curr Sci 2011; 101: 1191-1197.
  89. Validandi V, Reddy VS, Srinivas PN, Mueller NH, Bhagyalaxmi SG, Padma T, Petrash JM, Reddy GB. Temperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: molecular basis for early onset of age-related cataract. FEBS Lett. 2011 Dec 15; 585(24):3884-9 PMID: 22085609
  90. Satyanarayana A, Balakrishna N, Pitla S, Reddy PY, Mudili S, Lopamudra P, Suryanarayana P, Viswanath K, Ayyagari R, Reddy GB. Status of B-vitamins and homocysteine in diabetic retinopathy: association with vitamin-B12 deficiency and hyperhomocysteinemia. PLoS One. 2011; 6(11):e26747.PMID: 22069468
  91. Muthenna P, Akileshwari C, Reddy GB. Ellagic acid, a new antiglycating agent: its inhibition of Nϵ-(carboxymethyl)lysine. Biochem J. 2012 Feb 15; 442(1):221-30 PMID: 22060242
  92. Suryanarayana P, Patil MA, Reddy GB. Insulin resistance mediated biochemical alterations in eye lens of neonatal streptozotocin-induced diabetic rat. Indian J Exp Biol. 2011; 49:749-55. PMID: 22013741
  93. Vasireddy V, Chavali VR, Joseph VT, Kadam R, Lin JH, Jamison JA, Kompella UB, Reddy GB, Ayyagari R. Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation. PLoS One. 2011; 6(6):e21193. PMID: 21738619
  94. Kumar PA, Reddy PY, Suryanarayana P, Reddy GB. Effect of tannoids enriched fraction of Emblica officinalis on a-crystallin chaperone activity under hyperglycemic conditions in lens organ culture. J Biophys Struct Biol 2011; 3: 24-29
  95. Mrudula T, Ghafoorunissa, Saravanan N and Reddy GB.  Effects of prenatal and postnatal dietary polyunsaturated fatty acids on retinal fatty acid composition and gene expression in adult rat. J Food Sci Nutr 2011; 1: 102 (doi:10.4172/2155-9600.1000102)
  96. Zablocki GJ, Ruzycki PA, Overturf MA, Palla S, Reddy GB, Petrash JM. Aldose reductase-mediated induction of epithelium-to-mesenchymal transition in lens. Chem Biol Interact. 2011; 191:351-6. PMID: 21329682
  97. Srinivas PN, Patil MA, Reddy GB. Temperature-dependent coaggregation of eye lens αB- and β-crystallins. Biochem Biophys Res Commun. 2011 Feb 18; 405(3):486-90. PMID: 21256113
  98. Srinivas P, Narahari A, Petrash JM, Swamy MJ, Reddy GB. Importance of eye lens α-crystallin heteropolymer with 3:1 αA to αB ratio: stability, aggregation, and modifications. IUBMB Life. 2010; 62:693-702. PMID: 20836128
  99. Saraswat M, Suryanarayana P, Reddy PY, Patil MA, Balakrishna N, Reddy GB. Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. Mol Vis. 2010 Aug 10; 16:1525-37. PMID: 20806076
  100. Huang SP, Palla S, Ruzycki P, Varma RA, Harter T, Reddy GB, Petrash JM. Aldo-keto reductases in the eye. J Ophthalmol. 2010; 2010:521204.  PMID: 20628518
Total number of books and book chapters: 7 ; Total number of books and book chapters in the LAST 10 YEARS
  1. SS Reddy, GB, Reddy and K Krishnaswamy. Case studies on functional foods-Health benefits of turmeric (Curcumin longa Linn). In: Functional Foods Monographs 2017. ILSI Southeast Asia Region Monograph Series, 2018, pp32-27.
  2. GB Reddy.Prospects of nutrigenomics for public health nutrition in India: Opportunities & challenges. In: Insights on Global Challenges and Opportunities for the Century Ahead. (Eds: VD Reddy, KV Rao and K. Rama Krishna, pp 217-224, Osmania University Centenary Celebrations (1917-2017), 2017. BS Publications, Hyderabad
  3. GB Reddy, PS Chitra and N Arlappa. Aging: health and nutrition in Textbook of Human Nutrition (eds: M.S. Bamji, K. Krishnaswamy& G. N. V. Brahmam) 4rdEdn, pp 445-464, 2016, Oxford & IBH, New Delhi
  4. K Krishnaswamy and GB Reddy. Water soluble vitamins-deficiency disorders in Textbook of Human Nutrition eds: M.S. Bamji, K. Krishnaswamy& G. N. V. Brahmam) 4rdEdn, pp 336-357, 2016, Oxford & IBH, New Delhi.
  5. N Lakshmaiah, AV Lakshmi and GB Reddy. Water soluble vitamins in Textbook of Human Nutrition eds: M.S. Bamji, K. Krishnaswamy& G. N. V. Brahmam) 4rdEdn, 63-84, 2016, Oxford & IBH, New Delhi.
  6. GB Reddy and P Suryanarayana. Diabetes and diabetic complications and PhyllanthusspinPhyllanthus species: Scientific Evaluation and Medicinal Applications (eds: K. B. Hari Kumar &RamadasKuttan), pp 235-253, 2011, Taylor & Francis Group.
Awards and recognitions
  1. Fellow, Royal Society of Chemistry (London, UK) - 2019
  2. Founding Fellow, Telangana Academy of Sciences, India – 2015
  3. Fellow, AP Akademi of Sciences, India – 2012
  4. Fellow, National Academy of Sciences, India - 2006
  5. ICMR-Basanti Devi Amir Chand Prize – 2010
  6. Scopus India Young Scientist Award (Medicine) – 2008
  7. Research to Prevent Blindness (USA)-International Research Scholars Award - 2007
  8. ICMR Dr. V. N. Patwardhan Prize – 2002
  9. Young Scientist Award, Nutrition Society of India – 1994
  10. ICMR International Fellowship (for Senior Scientists)– 2017
  11. Gates Foundation Global Health Travel Award – 2015
  12. Eminent Research Supervisor Award by Dr. KV Rao Scientific Society – 2015
  13. Department of Health Research (DHR) Short-term Fellowship – 2014
  14. DBT-Associateship for Young Scientists (Niche Areas of Biotechnology) 2006-07
  15. Prof. BK. Bachhawat International Travel Grant for Young Scientist-2007
  16. ICMR International Fellowship – 2005
  17. CSIR-UGC Research Fellowship- 1990-95
  18. National Merit Scholarship- 1982-90
  19. Associate Editor: Journal of Food Science & Technology
  20. Subject Editor: Proceedings of National Academy of Sciences, India
  21. Regional Coordinator, Telangana Academy of Sciences (2015-)
  22. Member, Board of Governors, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad (2019-22)
  23. Member, Scientific Panel on Functional Food and Nutraceuticals, Food Safety and Standards Authority of India-FSSAI (2017-19)