Scientist ‘G’ & Head 
BIOCHEMISTRY


Email:   geereddy@yahoo.com
Email:  reddyg.bp@icmr.gov.in
Contact:  +91-40-27197252

Brief Profile

Obtained PhD in Biochemistry from Osmania University; Postdoctoral research training at the Indian Institute of Science, Bengaluru and Case Western Reserve University, Cleveland-USA. Major area of research interest is on molecular nutrition of chronic non-communicable disorders (NCD): the underlying basis of the disease, evaluation of nutritional status, study the role of micronutrients on molecular processes involved in NCD, investigate protective effect of functional foods, and developing suitable animal models. At present our focus is on micronutrient status of adult and geriatric-groups, influence of micronutrient on biomarkers of aging, and fibrotic mechanisms in age-related diseases. A part of the work deals protein quality control systems and its modulation by nutrition with respect to complications of diabetes and obesity. Developed a raw-food based quantitative food frequency questionnaire to quantify dietary intakes. We reported the prevalence of micronutrient deficiencies, identified the factors associated with inadequacy of micronutrient intakes and developed tools/biomarkers for assessing the micronutrient status. Our studies revealed a role for micronutrients in the development of diabetic complications and shown how deficiency of some micronutrients can influence the molecular processes and provided a basis for micronutrient involvement in diabetic complications. Our pioneering work on involvement protein glycation and aldoketo reductases under chronic hyperglycemia has led to the identification of novel bioactive molecules from functional foods against diabetic complications. We work with suitable animal models for studying the disease biology of complications of diabetes and obesity and to understand the role of nutrition. Described age-related eye diseases- neuronal and retinal degeneration and cataract, in a spontaneous obese rat model. Our studies provided new insights into the protein quality control mechanisms in chronic disorder and their modulation by nutritional factors.

Total Publications:216 (Total Impact Factor: 873; h-index:49)
  1. SS Reddy, UR Addi, R Pullakhandam, GB Reddy. Dietary zinc deficiency disrupts skeletal muscle proteostasis and mitochondrial biology in rats. Nutrition. 2022 Feb 9; 98:111625. doi: 10.1016/j.nut.2022.111625. PMID: 35439650
  2. R Pullakhandam, S Ghosh, B Kulkarni, GB Reddy, H Rajkumar, U Kapil, S Deb, AV Kurpad and HS. Sachdev. Reference cut-offs to define low serum zinc concentrations in healthy 1-19 year old Indian children and adolescents. Eur J Clin Nutr. 2022 Feb 9. doi: 10.1038/s41430-022-01088-4; PMID: 35140314
  3. Padakandla SR, Das T, Sai Prashanthi G, Angadi KK, Reddy SS, Reddy GB, Shivaji S. Gut mycobiome dysbiosis in rats showing retinal changes indicative of diabetic retinopathy. PLoS One. 2022 Apr 19;17(4): e0267080. doi: 10.1371/journal.pone.0267080.PMID: 35439275
  4. CU Kumar, U Suryavanshi, V Sontake, PY Reddy, RS. Sankhala, MJ Swamy, GB Reddy. Differential effects of sorbitol on alpha-crystallin structure and function. Biochemistry (Moscow) 2022; 87 (2): 131-140
  5. R Nivetha, S Arvindh, AB Baba, DR Gade, G Gopal, K Chitrathara, KP Reddy, GB Reddy, S Nagini. Nimbolide, a neem limonoid inhibits angiogenesis in breast cancer by abrogating aldose reductase mediated IGF-1/PI3K/Akt signalling. Anti-Cancer Agents Med Chem. 2022 Feb 4. doi: 10.2174/1871520622666220204115151. PMID: 35125086
  6. UR Addi, S Jakhotia, SS Reddy, GB Reddy. Advanced glycation end products in brain aging. Chem Biol Interact. 2022 Mar 1;355: 109840. doi: 10.1016/j.cbi.2022.109840. PMID: 35104490
  7. CU Kumar, P Suryanarayana, SS Reddy, MA Patil, PM Chary, PU Kumar, GB Reddy. Protective effect of cinnamon on diabetic cardiomyopathy in nicotinamide-streptozotocin induced diabetic rat model. J Diabetes Metab Disord (2022). https://doi.org/10.1007/s40200-021-00948-3.
  8. CU Kumar, SS Reddy, GB Reddy. Alterations in cardiac tissue of a natural obese rat model: Implications for obesity-associated cardiomyopathy. Proc Natl Acad Sci India, Sec B, Biol Sci, (2022), doi.org/10.1007/s40011-021-01305-3.
  9. GB Reddy, S Tattari, S Ghosh, R Pullakhandam, NB Kumar, B Kulkarni, A Laxmaiah, U Kapil, S. Deb, R Hemalatha, AV Kurpad, HS Sachdev. Prevalence of vitamin A deficiency and dietary inadequacy in Indian school-age children and adolescents. Eur J Nutr. 2022 Feb;61(1):197-209. PMID: 34251518
  10. S Rajagopal, A Gupta, R Parveen, N Shukla, S Bhattacharya, J Naravula, SA Kumar S, P Mathur, A Simlot, S Mehta, C Bihari, S Mehta, AK Mishra, KM Medicherla, GB Reddy, N Sreenivasulu, PBK Kishor and P Suravajhala. Vitamin K in human health and metabolism: A nutrigenomics review. Trends Food Sci. 2022 Jan; 119: 412–427.
  11. P Savitikadi, R Pullakhandam, B Kulkarni, BN Kumar, GB Reddy, VS Reddy. Chronic effects of maternal low-protein and low-quality protein diets on body composition, glucose-homeostasis and metabolic factors, followed by reversible changes upon rehabilitation in adult rat offspring. Nutrients 2021 Nov 18; 13 (11): 4129. doi: 10.3390/nu13114129. PMID: 34172268
  12. GB Reddy, R Pullakhandam, T Shalini, B Kulkarni, HS Sachdev, AV Kurpad. Vitamin A supplementation and fortification programs in India: need for review. NFI Bullet. 2021 Oct; 4 (4):1-8
  13. Y Kollati, RRD Akella, SM Naushad, RK Patel, GB Reddy, VR Dirisala. Molecular insights into the role of genetic determinants of congenital hypothyroidism. Genomics Inform. 2021 Sept;19(3): e29. PMID: 34638176
  14. DA Srinivasarao, SS Reddy, GB Reddy, DS Katti. Simultaneous amelioration of diabetic ocular complications in lens and retinal tissues using a non-invasive drug delivery system. Int J Pharm. 2021 Sep 1:121045. doi: 10.1016/j.ijpharm.2021.121045. PMID: 34481006
  15. SR Padakandla, TP Das, P Gumpili, AK Kumar, SS Reddy, GB Reddy, S Shivaji. Dysbiosis in the gut microbiome in streptozotocin-induced diabetes rats and follow up during retinal changes. Invest Ophthalmol Vis Sci. 2021 Aug 2;62(10):31. doi: 10.1167/iovs.62.10.31. PMID: 34431974
  16. Kurpad AV, Ghosh S, Thomas T, Bandyopadhyay S, Goswami R, Gupta A, Gupta P, John AT, Kapil U, Kulkarni B, Kuriyan R, Madan J, Makkar S, Nair KM, Pullakhandam R, Reddy GB, Shah D, Sachdev HS. Perspective: When the cure might become the malady: the layering of multiple interventions with mandatory micronutrient fortification of foods in India. Am J Clin Nutr. 2021 Jul 28:nqab245. doi: 10.1093/ajcn/nqab245. PMID: 34320172
  17. GB Reddy, R Pullakhandam, S Ghosh, N Boiroju, S Tattari, A Laxmaiah, R Hemalatha, U Kapil, HS Sachdev, AV Kurpad. Reply to Letter to the Editor (by A Hasman et al.). Am J Clin Nutr. 2021 Jul 1;114(1):391-392. doi: 10.1093/ajcn/nqab180. PMID: 34228773
  18. KS Vimaleswaran, GB Reddy. Letter to the Editor on Guiding global best practice in personalized nutrition based on genetics: The development of a nutrigenomics care map. J Acad Nutr Diet. 2021 July. 121(7); 1215-1216
  19. GB Reddy, R Pullakhandam, S Ghosh, N Boiroju, S Tattari, A Laxmaiah, R Hemalatha, U Kapil, HS Sachdev, AV Kurpad. Reply to Letter to the Editor (by J Sheftel et al. and N Arlappa). Am J Clin Nutr. 2021 Jun 1;113(6):1709-1711. doi: 10.1093/ajcn/nqab106. PMID: 34060596
  20. B Kulkarni, R Peter, S Ghosh, R Pullakhandam, T Thomas, GB Reddy, H Rajkumar, U Kapil, S Deb, R Johnston, PK Agrawal, AD Wagt, AV Kurpad, HS Sachdev. Prevalence of iron deficiency and its socio-demographic patterning in Indian children and adolescents: findings from Comprehensive National Nutrition Survey. J Nutr. 2021 May 28:nxab145. doi:10.1093/jn/nxab145. PMID: 34049401.
  21. T Shalini, SS Jose, PS Prasanthi, N Balakrishna, K Viswanath, GB Reddy. Carotenoid status in patients with type 2 diabetes with and without retinopathy. Food Function 2021 May 21;12(10):4402-4410. PMID: 33928954
  22. R Pullakhandam, PK Agrawal, R Peter, S Ghosh, GB Reddy, B Kulkarni, T Thomas, AV Kurpad, HS Sachdev, A Porwal, N Khan, S Ramesh, R Acharya, A Sarna, U Kapil, H Rajkumar, AD Wagt, S Deb, R Johnston. Biochemical zinc deficiency in Indian children and adolescents: Findings from the Comprehensive National Nutrition Survey 2016-18. Am J Clin Nutr 2021 Apr 8:nqab066. doi: 10.1093/ajcn/nqab066. PMID: 33831945
  23. VS Reddy, S Pandarinath, M Archana, GB Reddy. Impact of chronic hyperglycemia on small heat shock proteins in diabetic rat brain. Arch Biochem Biophys. 2021 Apr 15; 701:108816. PMID: 33631184
  24. GB Reddy, R Pullakhandam, S Ghosh, N Boiroju, S Tattari, A Laxmaiah, R Hemalatha, U Kapil, HS Sachdev, AV Kurpad. Vitamin A deficiency among under-five year children in India: an analysis of national data sets to reflect on the need for vitamin A supplementation. Am J Clin Nutr. 2021 Apr 6;113(4):939-947. doi: 10.1093/ajcn/nqaa314. PMID: 33330941
  25. PS Chitra, D Chaki, TR Mokalla, AK Gadde, SG Agraharam, GB Reddy. Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes. Exp Eye Res 2020 Nov; 200:108230. PMID:32931824.
  26. Kollati Y, Akella RRD, Naushad SM, Borkar D, Thalla M, Nagalingam S, Lingappa L, Patel RK, Reddy GB, Dirisala VR. Newborn screening and single nucleotide variation profiling of TSHR, TPO, TG and DUOX2 candidate genes for congenital hypothyroidism. Mol Biol Rep. 2020 Sep 15. doi: 10.1007/s11033-020-05803-x. PMID:32930933.
  27. Kasam, S Ghandikota, D Soundararajan, GB. Reddy, SK. Huang, AG. Jegga, SK. Madala. Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis. EMBO Molecular Medicine. 2020 Sep; 12(9): e12131; PMID: 32761869
  28. Shalini, PS Chitra, BN Kumar, G Madhavi, GB Reddy. Frailty and nutritional status among urban older adults in South India. J Aging Res, 2020 July; 2020: 8763413. PMID: 32695510
  29. R Nishad, P Meshram, AK Singh, GB Reddy, AK Pasupulati. Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria. BMJ Open Diabetes Research & Care, 2020 Jun; 8(1): e001203. PMID: 32601154.
  30. Kollati Y, Akella RRD, Naushad SM, Thalla M, Reddy GB, Dirisala VR. The rs1991517 polymorphism is a genetic risk factor for congenital hypothyroidism. 3D Biotech 2020 Jun;10(6):285. PMID: 32550104
  31. SS Reddy, YK Prabhakar, CU Kumar, PY Reddy, GB Reddy. Effect of vitamin-B12 supplementation on retinal lesions in diabetic rats. Molecular Vision 2020, 26:311-325. PMID: 32355441
  32. G Praveen, T Shalini, M Sivaprasad, GB Reddy. Relative telomere length and mitochondrial DNA copy number with age: Association with plasma folate and vitamin B12. Mitochondrion. 2020 Jan; 51: 79-87. PMID: 31935457
  33. KK Godisela, SS Reddy, PY Reddy, CU Kumar, VS Reddy, R Ayyagari, GB Reddy. Sorbitol-mediated cellular stress response in obesity-associated retinal degeneration. Arch Biochem Biophys. 2020 Jan 15; 679:108207. PMID: 31760123
  34. RP Kshirsagar, AA Kulkarni, RS Chouthe, SK Pathan, HD Une, GB Reddy, PV Diwan, SA Ansari, JN Sangshetti. SGLT inhibitors as antidiabetic agents: a comprehensive review. RSC Advances, 2020; 10: 1733-1756. doi.org/10.1039/C9RA08706K.
  35. Dave VP. Susaimanickam PJ, Mir IA, Mariappan I, Basu S, Reddy BG, Pappuru RR, Jalali S, Das T. Learning curve of a trained vitreo-retinal surgeon in sub-retinal injections in a rat model: Implications for future clinical trials. Indian J Ophthalmol. 2019 Sep;67(9):1455-1458. PMID: 31436191.
  36. Reddy VS, Trinath J, Reddy GB. Implication of homocysteine in protein quality control processes. Biochemie. 2019 Jun 30. 165:19-31. PMID: 31269461
  37. Srinivasarao DA, Reddy SS, Reddy GB, Katti DS. Spatio-temporal control on the delivery of triamcinolone acetonide using polymeric nanoparticles reduces steroid induced cataract. Int J Pharm 2019 Sep 10;568:118474. doi: 10.1016/j.ijpharm.2019.118474. PMID: 31279055
  38. Reddy MR, Aidhen IS, Reddy UB and Reddy GB, Ingle K, Mukhopadhyay S. Synthesis of 4-c--d-glucosylated isoliquiritigenin and analogues as aldose reductase inhibitors. Eur J Org Chem 2019 June; 2019 (24): 3937-3948
  39. RK Kasam, GB Reddy, AG Jegga, SK Madala. Dysregulation of mesenchymal cell survival pathways in severe fibrotic lung disease: The effect of nintedanib therapy. Front Pharmacol 2019; 10: 532. PMID: 31156440
  40. Sivaprasad M, Shalini T, Reddy PY, Seshacharyulu M, Madhavi G, Kumar BN, Reddy GB. Prevalence of vitamin deficiencies in the apparently healthy urban adult population: assessed by sub-clinical status and dietary intakes. Nutrition 2019 July-Aug; 63-64:106-113. PMID: 30954757
  41. Reddy SS, Shruthi K, Joy D, Reddy GB. 4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system. Chem Biol Interact 2019 June; 306: 70-77. PMID: 30980806.
  42. Shalini T, Sivaprasad M, Balakrishna M, Madhavi G, Radhika MS, Pullakhandam R, Reddy GB. Micronutrient intakes and status assessed by probability approach among the urban adult population of Hyderabad city in South India. Eur J Nutr. 2019 Dec;58(8):3147-3159. PMID: 30511165.
  43. Shruthi K, Reddy SS, Chitra PS, Reddy GB. Ubiquitin‐proteasome system and ER stress in the brain of diabetic rats. J Cell Biochem. 2019 Apr;120 (4): 5962-5972.PMID: 30317658.
  44. Reddy VS, Ravindranath P, Ismail I, Pullakhandam R, Reddy GB. Nutrigenomics: Opportunities & challenges for public health nutrition (Invited Review). Indian J Med Res (Special Issue: Nutrition Research) 2018 Nov;148(5):632-641. PMID: 30666988
  45. Sontake V, Kasam RK, Sinner D, Reddy GB, White ES, Jegga AG, Madala SK. Wilms’ Tumor-1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease. JCI-Insight 2018; 3(16):e121252.
  46. Kishore TK, Baba AB, Kowshik J. Reddy GB, Nagini S. Gedunin, a neem limonoid in combination with epalrestat inhibits cancer hallmarks by attenuating aldose reductase-driven oncogenic signaling in SCC131 oral cancer cells. Anticancer Agents Med Chem 2018;18(14):2042-2052. PMID: 30062975
  47. Mahaling B, Srinivasarao DA, Raghu G, Kasam R, Reddy GB, Katti DS. A non-invasive nanoparticle mediated delivery of triamcinolone acetonide ameliorates diabetic retinopathy in rats. Nanoscale 2018 Sep 13;10(35):16485-16498. PMID: 29897081
  48. Gopalakrishnan S, Ediga HH, Reddy SS, Reddy GB*, A Ismail. Procyanidin-B2 enriched fraction of cinnamon acts as a proteasome inhibitor and anti-proliferative agent in human prostate cancer cells. IUBMB Life. 2018. May;70(5):445-457. PMID: 29537730
  49. Thangella PAV, Pasumarti SNBS, Pullakhandam R, Reddy GB, Daggu MR. Differential expression of leaf proteins in four cultivars of peanut (Arachis hypogaea L) under water stress. 3D Biotech. 2018 Mar; 8(3):157; PMID: 29515963
  50. Reddy VS, Trinath J, Madala SK, Reddy GB. Extracellular small heat shock proteins: exosomal biogenesis and function. Cell Stress Chaperones. 2018 May; 23(3):441-454. PMID: 29086335
  51. Jakhotia S, Sivaprasad M, Shalini T, Reddy PY, Viswanath K, Jakhotia K, Sahay R, Sahay M, Reddy GB. Circulating levels of Hsp27 in microvascular complications of diabetes: Prospects as a biomarker of diabetic nephropathy. J Diabetes Complications. 2018 Feb; 32(2): 221-225. PMID: 29175119
  52. Reddy SS, Shruthi K, Prabhakar YK, Sailaja G, Reddy GB. Implication of altered ubiquitin-proteasome system and ER stress in the muscle atrophy of diabetic rats. Arch Biochem Biophys 2018. 639: 16-25. PMID: 29277369
  53. Jose SS, Shalini T, Balakrishna N, Radhika MS, Brahmam GNV, Reddy GB. Validity and reproducibility of a raw food based quantitative food frequency questionnaire (RFQNFFQ) across three seasons among urban adults of South India. Indian J Dietetics Nutr 2018; 55(1):1-17. DOI:10.21048/ijnd.2018.55.1.18269
  54. Reddy MR, Aidhen IS, Karnam S and Reddy GB. Synthesis of C-analogues of β-glucogallin and aldose reductase inhibition studies. Eur J Org Chem. 2017 Dec 29; 2017 (48): 7283–7294
  55. Singh S, Geddam JJ, Reddy GB, Pallepogula DR, HB Pant, SB Neogi, N John, SR Kolli, Doyle P, Kinra S, Ness A, Murthy GVS. Folate, vitamin B12, ferritin and haemoglobin levels among women of childbearing age from a rural district in South India. BMC Nutrition 2017; 3:50
  56. Raghu G, Akileshwari C, Reddy VS, Reddy GB. Attenuation of diabetic retinopathy in rats by ellagic acid through inhibition of AGE formation. J Food Sci Technol 2017. 54:2411–21. PMID: 28740299
  57. Shruthi K, Reddy SS, Reddy GB. Altered ubiquitin-proteasome system and declined autophagy leads to apoptosis in diabetic rat retina. Arch Biochem Biophys 2017; 627:10-20. PMID: 28606465
  58. Susaimanickam PJ, Maddileti S, Kumar V, Boyinpally SR, Naik RR, Naik MN, Reddy GB, Sangwan VS, Mariappan I. Generating minicorneal organoids from human induced pluripotent stem cells. Development. 2017 May 30; 144: 2338-2351 PMID: 28559289
  59. Godisela KK, Reddy SS, Kumar CU, Reddy PY, Jablonski MM, Ayyagar A, Reddy GB. Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome Mol Vis 2017; 23:263-274. PMID: 28465658
  60. Sontake V, Wang Y, Kasam RK, Reddy GB, Sinner D, Naren AP, McCormack FX, White ES, Jegga AG, Madala SK. Hsp90 regulation of fibroblast activation in pulmonary fibrosis. J Clin Invest-Insight 2017 Feb 23; 2(4):e91454. PMID: 28239659
Total number of books and book chapters: 7 ; Total number of books and book chapters in the LAST 5 YEARS
  1. G Praveen, M Sivaprasad, GB Reddy. Telomere length and vitamin B12. In Vitamins and Hormones, Vol 119: Vitamin B12 (Ed: Gerald Litwack), March 2022, Elsevier. doi: 10.1016/bs.vh.2022.01.014. Epub 2022 Feb 25. PMID: 35337624
  2. VS Reddy, J Trinath J, GB Reddy. Small heat shock proteins in inflammatory diseases. in Heat Shock Proteins in Inflammatory Diseases - Heat Shock Proteins-22 (Eds: AAA Asea and P Kaur). 2020; Springer https://doi.org/10.1007/7515_2020_9.
  3. SS Reddy, GB, Reddy and K Krishnaswamy. Case studies on functional foods-Health benefits of turmeric (Curcumin longa Linn). In: Functional Foods Monographs 2017. ILSI Southeast Asia Region Monograph Series, 2018, pp 32-27.
  4. GB Reddy, PS Chitra and N Arlappa. Aging: health and nutrition in Textbook of Human Nutrition (eds: M.S. Bamji, K. Krishnaswamy & G. N. V. Brahmam) 4rd Edn, pp 445-464, 2016, Oxford & IBH, New Delhi.
  5. K Krishnaswamy and GB Reddy. Water soluble vitamins-deficiency disorders in Textbook of Human Nutrition (eds: M.S. Bamji, K. Krishnaswamy & G. N. V. Brahmam) 4rd Edn, pp 336-357, 2016, Oxford & IBH, New Delhi
  6. N Lakshmaiah, AV Lakshmi and GB Reddy. Water soluble vitamins in Textbook of Human Nutrition (eds: M.S. Bamji, K. Krishnaswamy & G. N. V.Brahmam) 4rd Edn, 63-84, 2016, Oxford & IBH, New Delhi.
Awards and recognitions
  1. Fellow, National Academy of Medical Sciences - 2020
  2. Fellow, Royal Society of Chemistry (London, UK) - 2019
  3. Fellow, Telangana Academy of Sciences, India – 2015
  4. Fellow, AP Akademi of Sciences, India – 2012
  5. Fellow, National Academy of Sciences, India - 2006
  6. Bireswar Chakraborty Oration by ARVO-India Chapter, 2019
  7. Eminent Research Supervisor Award by Dr. KV Rao Scientific Society – 2015
  8. ICMR-Basanti Devi Amir Chand Prize – 2010
  9. Scopus India Young Scientist Award (Medicine) – 2008
  10. ICMR Dr. V. N. Patwardhan Prize – 2002
  11. Young Scientist Award, Nutrition Society of India – 1994
  12. Member, Governing Council, DBT-National Agri-Food Biotechnology Institute & DBT-Center of Innovative and Applied Bioprocessing, Mohali (2021-24)
  13. Member, Scientific Advisory Committee, DBT-National Agri-Food Biotechnology Institute & DBT-Center of Innovative and Applied Bioprocessing, Mohali (2021-24)
  14. Member, Research Council, CSIR-Central Food Technological Research Institute, Mysuru (2021-23)
  15. EC Member, Royal Society of Chemistry-Local Sections Deccan (2020-22)
  16. EC Member, Telangana Academy of Sciences (2018-21)
  17. Member, Board of Governors, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad (2019-22)
  18. Member, Scientific Panel on Functional Food and Nutraceuticals, Food Safety and Standards Authority of India-FSSAI (2017-19 & 2020-22)
  19. Associate Editor: Journal of Food Science & Technology
  20. Subject Editor: Proceedings of National Academy of Sciences, India