Scientist ‘G’ & Head 
BIOCHEMISTRY


Email:   geereddy@yahoo.com
Email:  reddyg.bp@icmr.gov.in
Contact:  +91-40-27197252

Brief Profile

PhD in Biochemistry (Osmania University); Postdoctoral research at the Indian Institute of Science, Bengaluru and Case Western Reserve University, Cleveland- USA. Worked as ICMR, DBT and DHR Fellows at the University of Michigan (2005 and 2007) and Cincinnati Children’s Hospital Medical Center (204), respectively.
His research is devoted to exploring on diverse facets of human nutrition ranging from deriving nutrient requirements to evaluating nutrient deficiencies, understanding the impact of food/nutrition on chronic diseases, and formulating dietary intervention strategies. He also delves into age-related disorders, with a particular focus on unraveling micronutrient-mediated molecular processes such as proteostasis and fibrotic mechanisms. Moreover, he investigates protective effects of functional foods and novel bioactive molecules. He reported the prevalence of micronutrient deficiencies and identified the factors contributing to inadequate micronutrient intakes. A major aspect of his research involves studying protein modifications by non-enzymatic glycation and aldo-keto reductases under conditions of chronic hyperglycemia. This research led to the discovery of novel bioactive molecules from functional foods, culminating in the development of functional food formulations targeting diabetes complications.  Additionally, his research sheds light on protein quality control mechanisms revealing insight into impaired ubiquitin-proteasome system, ER stress, and autophagy in conditions such as muscle atrophy, retinal degeneration, and neuronal cell death associated with obesity and diabetes.

Total Publications:234 (h-index:55; i10-index:154; citations: 9765) Selected publications in THE LAST 5 YEARS
  1. S Jakhotia, R Kavvuri, S Raviraj, S Baishya, AK Pasupulati,GB Reddy*. Obesity- related glomerulopathy is associated with elevated WT1 expression in podocytes. Int J Obesity 2024 Mar 19; doi: 10.1038/s41366-024-01509-3. PMID: 38504059.
  2. M Sivaprasad, T Shalini, M Sahay, R Sahay, M Satyanarayanan,GB Reddy*. Plasma levels and dietary intake of minerals in patients with type 2 diabetes and chronic kidney disease: a case-control study. J Trace Elem Med Biol. 2024; 84: 127425. PMID: 38484635
  3. KK Kalahasti, CU Kumar, M Nagaraju, JM Petrash, SS Reddy, GB Reddy*. Mitigation of lens opacification by a functional food in a diabetic rodent model. Chem Biol Interact 2024 Jan 23; 390:110889. PMID: 38272248
  4. D Kavitake, S Tiwari, PB Devi, IA Shah, GB Reddy*, PH Shetty* .Production,purification, and functional characterization of glucan exopolysaccharide produced by Enterococcus hirae strain OL616073 of fermented food origin. Int J Biol Macromol 2024 Feb; 259:129105. PMID: 38176508.
  5. U Suryavanshi, KK Angadi, VS Reddy, GB Reddy*. Neuroprotective role of vitamin B12 in streptozotocin-induced diabetic rats. Chem Biol Interact. 2024 Jan 5; 387:110823. PMID: 38049026.
  6. SV Akkenepally, DJK Yombo, S Yerubandi, GB Reddy, Deshpande DA, FX McCormack, SK Madala. Interleukin 31 receptor alpha induces airway hyperresponsiveness in asthma. Nature Communications 2023 Dec 11;14(1):8207. PMID: 38081868
  7. HH. Ediga, P Hester, A Yepuri, GB Reddy, SK Madala. N ε -Carboxymethyl-lysine modification of extracellular matrix proteins augments fibroblast activation. internat J Mol Sci. 2023, 24 (21): 15811. PMID: 37958795
  8. PR Kallamadi, D Esari, UR Addi, R Kesavan, UK Putcha, N Siddavaram, GB Reddy*. Obesity-associated with prediabetes increases the risk of breast cancer development and progression- a study on an obese rat model with impaired glucose tolerance. Internat J Mol Sci, 2023; 24(14):11441. PMID: 37511200
  9. T Shalini, R Pullakhandam, S Ghosh, B Kulkarni, H Rajkumar, HS. Sachdev, AV Kurpad and GB Reddy*. Prevalence of vitamin B 12 and folate deficiencies in Indian children and adolescents. Nutrients, 2023; 15(13):3026. PMID: 37447351
  10. S Tattari, P Raghu, SM Gavaravarapu, N Bhatia, R Sarwal, H Rajkumar, GB Reddy. Nutritional requirements for the elderly in India: A status paper. Indian J Med Res. Sep 2022, 156: 411-420. DOI: 10.4103/ijmr.ijmr_2784_21. PMID: 36751740.
  11. UR Addi, S Jakhotia, SS Reddy, GB Reddy*. Advanced glycation end products in brain aging. Chem Biol Interact. 2022 Mar 1; 355: 109840. PMID: 35104490.
  12. R Pullakhandam, S Ghosh, B Kulkarni, GB Reddy, H Rajkumar, U Kapil, S Deb, AV Kurpad and HS. Sachdev. Reference cut-offs to define low serum zinc concentrations in healthy 1–19-year-old Indian children and adolescents. Eur J Clin Nutr. 2022 Aug;76(8):1150-1157; PMID: 35140314.
  13. GB Reddy, S Tattari, S Ghosh, R Pullakhandam, NB Kumar, B Kulkarni, A Laxmaiah, U Kapil, S. Deb, R Hemalatha, AV Kurpad, HS Sachdev. Prevalence of vitamin A deficiency and dietary inadequacy in Indian school-age children and adolescents. Eur J Nutr. 2022 Feb;61(1):197-209. PMID: 34251518
  14. GB Reddy, R Pullakhandam, S Ghosh, N Boiroju, S Tattari, A Laxmaiah, R Hemalatha, U Kapil, HS Sachdev, AV Kurpad. Vitamin A deficiency among under- five year children in India: an analysis of national data sets to reflect on the need for vitamin A supplementation. Am J Clin Nutr. 2021 Apr 6;113(4):939-947. PMID: 33330941
  15. T Shalini, SS Jose, PS Prasanthi, N Balakrishna, K Viswanath, GB Reddy*. Carotenoid status in patients with type 2 diabetes with and without retinopathy. Food Function 2021 May 21;12(10):4402-4410. PMID: 33928954
  16. RK. Kasam, S Ghandikota, D Soundararajan, GB. Reddy, SK. Huang, AG. Jegga, SK. Madala. Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis. EMBO Molecular Medicine . 2020 Sep; 12(9): e12131; PMID: 32761869
  17. R Nishad, P Meshram, AK Singh, GB Reddy, AK Pasupulati. Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria. BMJ Open Diabetes Research & Care, 2020 Jun; 8(1): e001203. PMID: 32601154.
  18. SS Reddy, YK Prabhakar, CU Kumar, PY Reddy, GB Reddy*. Effect of vitamin- B12 supplementation on retinal lesions in diabetic rats. Molecular Vision 2020, 26:311-325. PMID: 32355441
  19. G Praveen, T Shalini, M Sivaprasad, GB Reddy*. Relative telomere length and mitochondrial DNA copy number with age: Association with plasma folate and vitamin B12. Mitochondrion. 2020 Jan; 51: 79-87. PMID: 31935457
  20. KK Godisela, SS Reddy, PY Reddy, CU Kumar, VS Reddy, R Ayyagari, GB Reddy*. Sorbitol-mediated cellular stress response in obesity-associated retinal degeneration. Arch Biochem Biophys. 2020 Jan 15; 679:108207. PMID: 31760123
  21. Sivaprasad M, Shalini T, Reddy PY, Seshacharyulu M, Madhavi G, Kumar BN, GB Reddy*. Prevalence of vitamin deficiencies in the apparently healthy urban adult population: assessed by sub-clinical status and dietary intakes. Nutrition 2019 July- Aug; 63-64:106-113. PMID: 30954757
  22. Shalini T, Sivaprasad M, Balakrishna M, Madhavi G, Radhika MS, Pullakhandam R, GB Reddy*. Micronutrient intakes and status assessed by probability approach among the urban adult population of Hyderabad city in South India. Eur J Nutr. 2019 Dec;58(8):3147-3159. PMID: 30511165.
  23. Reddy VS, Ravindranath P, Ismail I, Pullakhandam R, GB Reddy*. Nutrigenomics: Opportunities & challenges for public health nutrition (Invited Review). Indian J Med Res (Special Issue: Nutrition Research) 2018 Nov;148(5):632-641. PMID: 30666988
  24. Sontake V, Kasam RK, Sinner D, Reddy GB, White ES, Jegga AG, Madala SK. Wilms’ Tumor-1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease. JCI-Insight 2018; 3(16):e121252.
  25. Shruthi K, Reddy SS, Reddy PY, Sivalingam P, Harishankar N, Reddy GB*. Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system. J Nutr Biochem. 2016 July. 33:73-81. PMID: 27260470
  26. Kumar PA, Welsh G, Raghu, Saleem M, Reddy GB*. Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes. Arch Biochem Biophys 2016 Jan 15; 590:10- 19. PMID: 26550927
  27. GB Reddy*, M Sivaprasad, T Shalini, A Satyanarayana, M Seshacharyulu, N Balakrishna, K Viswanath, M Sahay. Plasma vitamin D status in type 2 diabetes patients with and without retinopathy. Nutrition, 2015; 31(7-8):959-63. PMID: 26059368
  28. Muthenna P, Raghu G, Kumar PA, Surekha MV, Reddy GB*. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chem Biol Interact. 2014 Sep 6; 222C:68-76. PMID: 25199697
  29. Reddy VS, Raghu G, Reddy SS, Pasupulati AK, Suryanarayana P, Reddy GB*. Response of small heat shock proteins in diabetic rat retina. Invest Ophthalmol Vis Sci. 2013 Nov 19; 54(12):7674-82. PMID: 24159092
  30. Satyanarayana A, Balakrishna N, Pitla S, Reddy PY, Mudili S, Lopamudra P, Suryanarayana P, Viswanath K, Ayyagari R, Reddy GB*. Status of B-vitamins and homocysteine in diabetic retinopathy: association with vitamin-B12 deficiency and hyperhomocysteinemia. PLoS One. 2011; 6(11):e26747. PMID: 22069468
  31. Bhagyalaxmi SG, Srinivas P, Barton KA, Kumar KR, Vidyavathi M, Petrash JM, Bhanuprakash Reddy G*, Padma T. A novel mutation (F71L) in alphaA- crystallin with defective chaperone-like function associated with age-related cataract. Biochim Biophys Acta-MBD. 2009 Oct; 1792(10):974-81. PMID: 19595763
  32. GB Reddy*, Vasireddy V, Mandal MN, Tiruvalluru M, Wang XF, Jablonski MM, Nappanveettil G, Ayyagari R. A novel rat model with obesity-associated retinal degeneration. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3456-63. PMID: 19369235
  33. Saraswat M, Reddy PY, Muthenna P, Reddy GB*. Prevention of non-enzymic glycation of proteins by dietary agents: prospects for alleviating diabetic complications. Br J Nutr. 2009 Jun; 101(11):1714-21. PMID: 20806076
  34. MS Kumar, M Kapoor, S Sinha, GB Reddy*. Insights into hydrophobicity and the chaperone-like function of alphaA- and alphaB-crystallins: an isothermal titration calorimetric study. J Biol Chem. 2005; 280:21726-30. PMID: 15817465
  35. GB Reddy, KP Das, JM Petrash JM, WK Surewicz. Temperature-dependent chaperone activity and structural properties of human alphaA- and alphaB-crystallins. J Biol Chem. 2000 Feb 18; 275(7):4565-70. PMID: 10671481
  36. GB Reddy, VR Srinivas, N Ahmad, A Surolia. Molten globule-like state of peanut lectin monomer retains its carbohydrate specificity. Implications for protein folding and legume lectin oligomerization. J Biol Chem. 1999; 274:4500-3. PMID: 9988681
Total number of books/ book chapters :09
Books and book chapters in the LAST 5 YEARS
  1. AK Pasupulati, V Nagati, ASV Paturii, Reddy*. Non-enzymatic glycation and diabetic kidney diseases. In Vitamins and Hormones, Vol 124 (Glycation): xxx-xxx (Ed: Gerald Litwack), Feb 06, 2024, Academic Press. ISBN 0083-6729.https://doi.org/10.1016/bs.vh.2024.01.002
  2. G Praveen, M Sivaprasad, GB Reddy. Telomere length and vitamin B12. In Vitamins and Hormones, Vol 119: Vitamin B12 (Ed: Gerald Litwack), March 2022, Elsevier. doi: 10.1016/bs.vh.2022.01.014. Epub 2022 Feb 25. PMID: 35337624
  3. VS Reddy, J Trinath J, GB Reddy. Small heat shock proteins in inflammatory diseases. in Heat Shock Proteins in Inflammatory Diseases - Heat Shock Proteins-22 (Eds: AAA Asea and P Kaur). 2020; Springer https://doi.org/10.1007/7515_2020_9.
  4. SS Reddy, GB Reddy and K Krishnaswamy. Case studies on functional foods-Health benefits of turmeric (Curcumin longa Linn). In: Functional Foods Monographs 2017. ILSI Southeast Asia Region Monograph Series, 2018, pp 32-27.
Awards and recognitions
  1. Fellow, International Union of Nutritional Sciences-2022
  2. Fellow, National Academy of Medical Sciences - 2020
  3. Fellow, Royal Society of Chemistry (London, UK) - 2019
  4. Fellow, Telangana Academy of Sciences, India – 2015
  5. Fellow, AP Akademi of Sciences, India – 2012
  6. Fellow, National Academy of Sciences, India - 2006
  7. Vepachedu Gopalkishan Rao Memorial Endowment Award - 2023
  8. Bireswar Chakraborty Oration by ARVO-India Chapter, 2019
  9. Gates Foundation Global Health Travel Award - 2015
  10. Eminent Research Supervisor Award-2015
  11. ICMR-Basanti Devi Amir Chand Prize – 2010
  12. Scopus India Young Scientist Award (Medicine) – 2008
  13. ICMR Dr. V. N. Patwardhan Prize – 2002
  14. Chairman, INSA-National Committee for International Union of Nutritional Sciences-2024-26
  15. Vice-President, Nutrition Society of India (2024-26)
  16. Vice-President: Telangana Academy of Sciences (2023-25)
  17. Hon. Associate Editor: Indian Journal of Medical Research
  18. Subject Editor: Proceedings of National Academy of Sciences, India